An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling. (English) Zbl 1255.92015
Summary: We present major results from a novel dynamic model intended to deterministically represent the complex relation between HIV-1 and the human immune system. The novel structure of the model extends previous work by representing different host anatomic compartments under a more in-depth cellular and molecular immunological phenomenology. Recently identified mechanisms related to HIV-1 infection as well as other well known relevant mechanisms typically ignored in mathematical models of HIV-1 pathogenesis and immunology, such as cell-cell transmission, are also addressed.
MSC:
| 92C60 | Medical epidemiology |
References:
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