Summary: In this study, analytical examination of effects of internal heat generation, thermal radiation, and buoyancy force on flow and heat transfer in the Blasius flow over flat plate has been presented. The governing nonlinear partial differential equations of the problem are transformed into a set of coupled nonlinear third-order ordinary differential equations by the similarity variable method and have been systematically solved using the optimal homotopy asymptotic method. The main aim of the present study is to inspect the effects of various physical parameters in the flow model on velocity and heat transfer in steady two-dimensional laminar boundary layer flow with convective boundary conditions. The influences of the Grashof number, internal heat generation, the Biot number, radiation parameter, and the Prandtl number on the skin-friction coefficient, the fluid velocity profile, and temperature distribution have been determined and discussed in detail through several plots. The finding revealed that the fluid velocity and temperature delivery upsurge with snowballing in the values of the Biot number and internal heat generation parameters. The temperature profile of the fluid declines contrary to the value of the Grashof number and the Prandtl number but increases with thermal radiation. Moreover, it is found that the skin-friction coefficient and the rate of heat intensify with the Grashof number, internal heat generation, the Biot number, and thermal radiation parameter. The obtained result is likened with the previously published numerical results in a limited case of the problem and shows an excellent agreement.