Summary: Motivated by the three-dimensional topological field theory/two-dimensional conformal field theory (CFT) correspondence, we study a broad class of one-dimensional quantum mechanical models, known as anyonic chains, which can give rise to an enormously rich (and largely unexplored) space of two-dimensional critical theories in the thermodynamic limit. One remarkable feature of these systems is the appearance of non-local microscopic “topological symmetries” that descend to topological defects of the resulting CFTs. We derive various model-independent properties of these theories and of this topological symmetry/topological defect correspondence. For example, by studying precursors of certain twist and defect fields directly in the anyonic chains, we argue that (under mild assumptions) the two-dimensional CFTs correspond to particular modular invariants with respect to their maximal chiral algebras and that the topological defects descending from topological symmetries commute with these maximal chiral algebras. Using this map, we apply properties of defect Hilbert spaces to show how topological symmetries give a handle on the set of allowed relevant deformations of these theories. Throughout, we give a unified perspective that treats the constraints from discrete symmetries on the same footing as the constraints from topological ones.