×

Regression analysis of general mixed recurrent event data. (English) Zbl 07769325

Summary: In modern biomedical datasets, it is common for recurrent outcomes data to be collected in an incomplete manner. More specifically, information on recurrent events is routinely recorded as a mixture of recurrent event data, panel count data, and panel binary data; we refer to this structure as general mixed recurrent event data. Although the aforementioned data types are individually well-studied, there does not appear to exist an established approach for regression analysis of the three component combination. Often, ad-hoc measures such as imputation or discarding of data are used to homogenize records prior to the analysis, but such measures lead to obvious concerns regarding robustness, loss of efficiency, and other issues. This work proposes a maximum likelihood regression estimation procedure for the combination of general mixed recurrent event data and establishes the asymptotic properties of the proposed estimators. In addition, we generalize the approach to allow for the existence of terminal events, a common complicating feature in recurrent event analysis. Numerical studies and application to the Childhood Cancer Survivor Study suggest that the proposed procedures work well in practical situations.

MSC:

62Nxx Survival analysis and censored data
62P10 Applications of statistics to biology and medical sciences; meta analysis
Full Text: DOI

References:

[1] Brewster, D.; Clark, D.; Hopkins, L.; Bauer, J.; Wild, S.; Edgar, A.; Wallace, W., Subsequent hospitalisation experience of 5-year survivors of childhood, adolescent, and young adult cancer in scotland: a population based, retrospective cohort study, Brit J Cancer, 110, 5, 1342-1350 (2014) · doi:10.1038/bjc.2013.788
[2] Bycroft, C.; Freeman, C.; Petkova, D.; Band, G.; Elliott, LT; Sharp, K.; Motyer, A.; Vukcevic, D.; Delaneau, O.; O’Connell, J., The UK Biobank resource with deep phenotyping and genomic data, Nature, 562, 7726, 203-209 (2018) · doi:10.1038/s41586-018-0579-z
[3] Casillas, J.; Castellino, SM; Hudson, MM; Mertens, AC; Lima, IS; Liu, Q.; Zeltzer, LK; Yasui, Y.; Robison, LL; Oeffinger, KC, Impact of insurance type on survivor-focused and general preventive health care utilization in adult survivors of childhood cancer: the childhood cancer survivor study (ccss), Cancer, 117, 9, 1966-1975 (2011) · doi:10.1002/cncr.25688
[4] Castellino, SM; Casillas, J.; Hudson, MM; Mertens, AC; Whitton, J.; Brooks, SL; Zeltzer, LK; Ablin, A.; Castleberry, R.; Hobbie, W., Minority adult survivors of childhood cancer: a comparison of long-term outcomes, health care utilization, and health-related behaviors from the childhood cancer survivor study, J Clin Oncol, 23, 27, 6499-6507 (2005) · doi:10.1200/JCO.2005.11.098
[5] Cook, RJ; Lawless, J., Cancer Epidemiology and Prevention Biomarkers (2007), Springer Science & Business Media
[6] Kirchhoff, AC; Fluchel, MN; Wright, J.; Ying, J.; Sweeney, C.; Bodson, J.; Stroup, AM; Smith, KR; Fraser, A.; Kinney, AY, Risk of hospitalization for survivors of childhood and adolescent cancer, Cancer Epidemiol Prev Biomark, 23, 7, 1280-1289 (2014) · doi:10.1158/1055-9965.EPI-13-1090
[7] Kurt, BA; Nolan, VG; Ness, KK; Neglia, JP; Tersak, JM; Hudson, MM; Armstrong, GT; Hutchinson, RJ; Leisenring, WM; Oeffinger, KC, Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort, Pediat Blood Cancer, 59, 1, 126-132 (2012) · doi:10.1002/pbc.24017
[8] Liu, L.; Huang, X.; Yaroshinsky, A.; Cormier, JN, Joint frailty models for zero-inflated recurrent events in the presence of a terminal event, Biometrics, 72, 1, 204-214 (2016) · Zbl 1393.62079 · doi:10.1111/biom.12376
[9] Mueller, EL; Park, ER; Kirchhoff, AC; Kuhlthau, K.; Nathan, PC; Perez, GK; Rabin, J.; Hutchinson, R.; Oeffinger, KC; Robison, LL, Insurance, chronic health conditions, and utilization of primary and specialty outpatient services: a childhood cancer survivor study report, J Cancer Surviv, 12, 5, 639-646 (2018) · doi:10.1007/s11764-018-0700-1
[10] Robison, LL; Armstrong, GT; Boice, JD; Chow, EJ; Davies, SM; Donaldson, SS; Green, DM; Hammond, S.; Meadows, AT; Mertens, AC, The childhood cancer survivor study: a national cancer institute-supported resource for outcome and intervention research, J Clin Oncol, 27, 14, 2308 (2009) · doi:10.1200/JCO.2009.22.3339
[11] Rosenberg, SM; Moskowitz, CS; Ford, JS; Henderson, TO; Frazier, AL; Diller, LR; Hudson, MM; Stanton, AL; Chou, JF; Smith, S., Health care utilization, lifestyle, and emotional factors and mammography practices in the childhood cancer survivor study, Cancer Epidemiol Prev Biomark, 24, 11, 1699-1706 (2015) · doi:10.1158/1055-9965.EPI-14-1377
[12] Sun J, Zhao X (2013) Statistical Analysis of Panel Count Data. Springer-Verlag, New York doi:10.1007/978-1-4614-8715-9 · Zbl 1282.62105
[13] Wellner, JA; Zhang, Y., Two estimators of the mean of a counting process with panel count data, Ann Stat, 28, 3, 779-814 (2000) · Zbl 1105.62372 · doi:10.1214/aos/1015951998
[14] Wellner, JA; Zhang, Y., Two likelihood-based semi- parametric estimation methods for panel count data with covariates, Ann Stat, 35, 1, 2106-2142 (2007) · Zbl 1126.62084
[15] Yu, G.; Zhu, L.; Li, Y.; Sun, J.; Robison, LL, Regression analysis of mixed panel count data with dependent terminal events, Stat Med, 36, 10, 1669-1680 (2017) · doi:10.1002/sim.7217
[16] Yu, G.; Li, Y.; Zhu, L.; Zhao, H.; Sun, J.; Robison, LL, An additive-multiplicative mean model for panel count data with dependent observation and dropout processes, Scand J Stat, 46, 2, 414-431 (2019) · Zbl 1418.62370 · doi:10.1111/sjos.12357
[17] Zhu, L.; Tong, X.; Zhao, H.; Sun, J.; Srivastava, DK; Leisenring, W.; Robison, LL, Statistical analysis of mixed recurrent event data with application to cancer survivor study, Stat Med, 32, 11, 1954-1963 (2013) · doi:10.1002/sim.5674
[18] Zhu, L.; Tong, X.; Sun, J.; Chen, M.; Srivastava, DK; Leisenring, W.; Robison, LL, Regression analysis of mixed recurrent-event and panel-count data, Biostatistics, 15, 3, 555-568 (2014) · doi:10.1093/biostatistics/kxu009
[19] Zhu, L.; Zhao, H.; Sun, J.; Leisenring, W.; Robison, LL, Regression analysis of mixed recurrent-event and panel-count data with additive rate models, Biometrics, 71, 1, 71-79 (2015) · Zbl 1419.62496 · doi:10.1111/biom.12247
[20] Zhu, L.; Zhang, Y.; Li, Y.; Sun, J.; Robison, LL, A semiparametric likelihood-based method for regression analysis of mixed panel-count data, Biometrics, 74, 2, 488-497 (2018) · Zbl 1415.62152 · doi:10.1111/biom.12774
[21] Zhu, L.; Choi, S.; Li, Y.; Huang, X.; Sun, J.; Robison, LL, Statistical analysis of clustered mixed recurrent-event data with application to a cancer survivor study, Lifetime Data Anal, 26, 4, 820-832 (2020) · Zbl 1457.62328 · doi:10.1007/s10985-020-09500-6
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.