×

Global boundedness and asymptotic behavior in a double haptotaxis model for oncolytic virotherapy. (English) Zbl 07922121

Summary: This work studies a haptotactic cross-diffusion system modeling oncolytic virotherapy \[ \begin{cases} u_t = \Delta u - \nabla \cdot (u \nabla v) - \rho u z, \\ v_t = - (u + w) v - \kappa v, \\ w_t = D_w \Delta w - \xi_w \nabla \cdot (w \nabla v) - w + \rho u z, \\ z_t = D_z \Delta z - z - \rho u z + \beta w, \end{cases} \] in a smooth bounded domain \(\Omega \subset \mathbb{R}^2\), with parameters \(D_w > 0\), \(D_z > 0\), \(\xi_w \geq 0\), \(\rho \geq 0\), \(\kappa > 0\) and \(\beta \geq 0\). This system describes the interaction among uninfected and infected cancer cells, extracellular matrix and oncolytic viruses. It is rigorously proved that an associated no-flux initial-boundary value problem has a unique global classical solution which is bounded in \((L^\infty (\Omega))^4\). Moreover, it is shown that this bounded solution can approach a spatially constant equilibrium in the large time limit under the additional assumption that \(0 \leq \beta < 1\).

MSC:

35B40 Asymptotic behavior of solutions to PDEs
35K51 Initial-boundary value problems for second-order parabolic systems
35Q92 PDEs in connection with biology, chemistry and other natural sciences
Full Text: DOI

References:

[1] Alzahrani, T.; Eftimie, R.; Trucu, D., Multiscale modelling of cancer response to oncolytic viral therapy, Math. Biosci., 310, 76-95, 2019 · Zbl 1425.92103
[2] Chen, Z., Dampening effect of logistic source in a two-dimensional haptotaxis system with nonlinear zero-order interaction, J. Math. Anal. Appl., 492, Article 124435 pp., 2020 · Zbl 1462.35412
[3] Fukuhara, H.; Ino, Y.; Todo, T., Oncolytic virus therapy: a new era of cancer treatment at dawn, Cancer Sci., 107, 1373-1379, 2016
[4] Horstmann, D.; Winkler, M., Boundedness vs. blow-up in a chemotaxis system, J. Differ. Equ., 215, 52-107, 2005 · Zbl 1085.35065
[5] Lawler, S.; Speranza, M.; Cho, C.; Chiocca, E., Oncolytic viruses in cancer treatment: a review, JAMA Oncol., 3, 841-849, 2017
[6] Li, J.; Wang, Y., Boundedness in a haptotactic cross-diffusion system modeling oncolytic virotherapy, J. Differ. Equ., 270, 94-113, 2021 · Zbl 1452.35077
[7] Tao, Y., Global existence for a haptotaxis model of cancer invasion with tissue remodeling, Nonlinear Anal., Real World Appl., 12, 418-435, 2011 · Zbl 1205.35144
[8] Tao, X., Global classical solutions to an oncolytic viral therapy model with triply haptotactic terms, Acta Appl. Math., 171, 5, 2021 · Zbl 1464.35379
[9] Tao, X., Global weak solutions to an oncolytic viral therapy model with doubly haptotactic terms, Nonlinear Anal., Real World Appl., 60, Article 103276 pp., 2021 · Zbl 1466.92083
[10] Tao, Y.; Winkler, M., Energy-type estimates and global solvability in a two-dimensional chemotaxis-hapotaxis model with remodeling of non-diffusible attractant, J. Differ. Equ., 257, 784-815, 2014 · Zbl 1295.35144
[11] Tao, Y.; Winkler, M., Large time behavior in a multidimensional chemotaxis-haptotaxis model with slow signal diffusion, SIAM J. Math. Anal., 47, 4229-4250, 2015 · Zbl 1328.35103
[12] Tao, Y.; Winkler, M., A critical virus production rate for blow-up suppression in a haptotaxis model for oncolytic virotherapy, Nonlinear Anal., 198, Article 111870 pp., 2020 · Zbl 1442.35480
[13] Tao, Y.; Winkler, M., Global classical solutions to a doubly haptotactic cross-diffusion system modeling oncolytic virotherapy, J. Differ. Equ., 268, 4973-4997, 2020 · Zbl 1430.35132
[14] Tao, Y.; Winkler, M., A critical virus production rate for efficiency of oncolytic virotherapy, Eur. J. Appl. Math., 32, 301-316, 2021 · Zbl 1526.92012
[15] Tao, Y.; Winkler, M., Critical mass for infinite-time blow-up in a haptotaxis system with nonlinear zero-order interaction, Discrete Contin. Dyn. Syst., Ser. A, 41, 439-454, 2021 · Zbl 1458.35076
[16] Tao, Y.; Winkler, M., Asymptotic stability of spatial homogeneity in a haptotxis model for oncolytic virotherapy, Proc. R. Soc. Edinb., Sect. A, 152, 81-101, 2022 · Zbl 1484.35363
[17] Tao, X.; Zhou, S., Dampening effects on global boundedness and asymptotic behavior in an oncolytic virotherapy model, J. Differ. Equ., 308, 57-76, 2022 · Zbl 1479.35119
[18] Tao, X.; Zhou, S., Boundedness in a chemotaxis-May-Nowak model for virus dynamics with mildly saturated chemotactic sensitivity and conversion, Discrete Contin. Dyn. Syst., Ser. B, 28, 5269-5280, 2023 · Zbl 1516.35091
[19] Wang, Y.; Xu, C., Asymptotic behaviour in a doubly haptotactic cross-diffusion model for oncolytic virotherapy, Proc. R. Soc. Edinb., Sect. A, 153, 881-906, 2023 · Zbl 1518.35121
[20] Wang, Y.; Xu, C., Asymptotic behavior of a three-dimensional haptotactic cross-diffusion system modeling oncolytic virotherapy, Math. Models Methods Appl. Sci., 33, 2313-2335, 2023 · Zbl 1530.35126
[21] Wei, Y.; Wang, Y.; Li, J., Asymptotic behavior for solutions to an oncolytic virotherapy model involving triply haptotactic terms, Z. Angew. Math. Phys., 73, 55, 2022 · Zbl 1485.35064
[22] Winkler, M., Aggregation vs. global diffusive behavior in the higher-dimensional Keller-Segel model, J. Differ. Equ., 248, 2889-2905, 2010 · Zbl 1190.92004
[23] Winkler, M., Singular structure formation in a degenerate haptotaxis model involving myopic diffusion, J. Math. Pures Appl., 112, 118-169, 2018 · Zbl 1391.35065
[24] Zheng, J.; Ke, Y., Boundedness and large time behavior of solutions of a higher-dimensional haptotactic system modeling oncolytic virotherapy, Math. Models Methods Appl. Sci., 33, 1875-1907, 2023 · Zbl 1519.35032
[25] Zheng, J.; Xie, J., Global classical solutions to a higher-dimensional doubly haptotactic cross-diffusion system modeling oncolytic virotherapy, J. Differ. Equ., 340, 111-150, 2022 · Zbl 1500.35067
This reference list is based on information provided by the publisher or from digital mathematics libraries. Its items are heuristically matched to zbMATH identifiers and may contain data conversion errors. In some cases that data have been complemented/enhanced by data from zbMATH Open. This attempts to reflect the references listed in the original paper as accurately as possible without claiming completeness or a perfect matching.