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Model hierarchies for cell aggregation by chemotaxis. (English) Zbl 1094.92009

Summary: We present partial differential equation (PDE) model hierarchies for the chemotactically driven motion of biological cells. Starting from stochastic differential models, we derive a kinetic formulation of cell motion coupled to diffusion equations for the chemoattractants. We also derive a fluid dynamic (macroscopic) Keller-Segel type chemotaxis model by scaling limit procedures. We review rigorous convergence results and discuss finite-time blow-up of Keller-Segel type systems. Finally, recently developed PDE-models for the motion of leukocytes in the presence of multiple chemoattractants and of the slime mold Dictyostelium Discoideum are reviewed.

MSC:

92C17 Cell movement (chemotaxis, etc.)
35K57 Reaction-diffusion equations
60H15 Stochastic partial differential equations (aspects of stochastic analysis)
35Q92 PDEs in connection with biology, chemistry and other natural sciences
60J70 Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.)
Full Text: DOI

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