Summary: Coding in a new metric space, called the Enomoto-Katona space, has recently been considered in connection with the study of implication structures of functional dependencies and their generalizations in relational databases. The central problem is the determination of \({C}({n,k,d})\), the size of an optimal code of length \(n\), weight \(k\), and distance \(d\) in the Enomoto-Katona space. The value of \({C}({n,k,d})\) was known only for some congruence classes of \(n\) when \(({k,d})\in \{(2,3),(3,5)\}\). In this paper, we obtain new infinite families of optimal codes in the Enomoto-Katona space and verify a conjecture of Brightwell and Katona in certain instances. In particular, \({C}({n},{k}, 2{k} - 1)\) is determined for all sufficiently large \(n\) satisfying either \(n\equiv 1 \mod {k}\) and \({n}({n} - 1)\equiv 0 \mod {2k^2}\), or \(n\equiv 0 \mod {k}\). We also give complete solutions for \({k}=2\) and determine \({C}({n},3,5)\) for certain congruence classes of \(n\) with finite exceptions.