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Inference based on kernel estimates of the relative risk function in geographical epidemiology. (English) Zbl 1442.62407

Summary: Kernel smoothing is a popular approach to estimating relative risk surfaces from data on the locations of cases and controls in geographical epidemiology. The interpretation of such surfaces is facilitated by plotting of tolerance contours which highlight areas where the risk is sufficiently high to reject the null hypothesis of unit relative risk. Previously it has been recommended that these tolerance intervals be calculated using Monte Carlo randomization tests. We examine a computationally cheap alternative whereby the tolerance intervals are derived from asymptotic theory. We also examine the performance of global tests of hetereogeneous risk employing statistics based on kernel risk surfaces, paying particular attention to the choice of smoothing parameters on test power

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis

Software:

pyuvdata
Full Text: DOI