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Exact one-sided confidence bounds for the risk ratio in \(2\times 2\) tables with structural zero. (English) Zbl 1442.62508

Summary: This paper examines exact one-sided confidence limits for the risk ratio in a \(2\times 2\) table with structural zero. Starting with four approximate lower and upper limits, we adjust each using the algorithm of Buehler (1957) to arrive at lower (upper) limits that have exact coverage properties and are as large (small) as possible subject to coverage, as well as an ordering, constraint. Different Buehler limits are compared by their mean size, since all are exact in their coverage. Buehler limits based on the signed root likelihood ratio statistic are found to have the best performance and recommended for practical use.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
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