A spatial model of cellular molecular trafficking including active transport along microtubules. (English) Zbl 1414.92132
Summary: We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally.
MSC:
| 92C37 | Cell biology |
| 92C45 | Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) |
| 35Q92 | PDEs in connection with biology, chemistry and other natural sciences |
Keywords:
signal transduction; intracellular transport; protein motors; microtubules; discontinuous Galerkin methodsSoftware:
deal.iiReferences:
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