A folding “framework structure” of Tetrahymena group I intron. (English) Zbl 1414.92205
Summary: We have published the dynamic extended folding (DEF) method, which is a RNA secondary structure prediction approach – to simulate the in vivo RNA co-transcriptional folding process. In order to verify the reliability of the method, we selected the X-ray-determined Tetrahymena group I intron as a sample to construct the framework of its folding secondary structure. Our prediction coincides well with the secondary structure predicted by T. R. Cech and the X-ray diffraction crystal structure determined by Lehnert V. Our results show that the DEF framework structure of Tetrahymena group I intron reflects its function sites in a concise and straightforward manner, and the scope of the simulation was expanded.
MSC:
| 92D20 | Protein sequences, DNA sequences |
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