Summary: The results of neurophysiological and modeling studies focused on activity synchronization among different types of neurons and spike shape dynamics in two bistability transition states have been presented. In the modeling study, the spike duration range of “fast” and“slow” neurons recorded in neurophysiological experiments were simulated. By simulation of the model element groups with different properties of short-term and long-term activity dynamics, it was revealed that the degree of their activity synchronization depends on frequency and power of input influences; it was maximal at high frequency of super threshold input signals. A possible approach to the study of column functioning mechanisms and dynamics operations inside the columns have been considered.