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Logistic analysis in case-control studies under validation sampling. (English) Zbl 0783.62097

Summary: This paper proposes an analysis of case-control data under a double- sampling scheme, when covariates are missing or measured with error at the first stage of sampling and are validated at the second stage in a subsample. The method combines risk information from both samples. It is derived under the assumptions that (i) the prospective disease incidence model is of logistic form, (ii) the proxy or partial information takes on finitely many values, and (iii) the error is nondifferential.
The method of R. L. Prentice and R. Pyke [ibid. 66, 403-411 (1979; Zbl 0428.62078)] is extended to a two-sample design to derive an estimating equation for the odds-ratio parameters. It provides an alternative estimator to that given by N. E. Breslow and K. C. Cain [ibid. 75, No. 1, 11-20 (1988; Zbl 0635.62110)]. Consistency and asymptotic normality of the estimates are derived and a variance formula is presented. Parameters can be estimated by use of standard packages for quantal-response data. The method can easily be extended to the analysis of stratified designs with large strata.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
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