Optimal intervention strategies of a SI-HIV models with differential infectivity and time delays. (English) Zbl 1437.92110
Summary: HIV infection is divided into stages of infection which are determined by the CD4 cells count progression. Through each stage, the time delay for the progression is important because the duration of HIV infection varies according to the infectious. Retarded optimal control theory is applied to a system of delays ordinary differential equations modeling the evolution of HIV with differential infectivity. Seeking to reduce the population of the infective individuals with low CD4 cells, we use the ARV drug to control the fraction of infective individuals that is identified and will be put under treatment. We use optimal control theory to study our proposed system. Numerical simulations are provided to illustrate the effect of the antiretroviral treatment (ART) taking into account the delays.
MSC:
| 92D30 | Epidemiology |
| 92C60 | Medical epidemiology |
| 49K15 | Optimality conditions for problems involving ordinary differential equations |
| 34K35 | Control problems for functional-differential equations |
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