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Semiparametric least-squares regression with doubly-censored data. (English) Zbl 07422872

Summary: Double censoring often occurs in biomedical research, such as HIV/AIDS clinical trials, when an outcome of interest is subject to both left censoring and right censoring. It can also be seen as a mixture of exact and current status data and has long been investigated by several authors for theoretical and practical purposes. In this article, we propose the Buckley-James method for an accelerated failure time model under double random censoring. For the semiparametric inference, where the error distribution of the censored linear model is left unspecified, we develop an efficient EM-based self-consistency procedure to estimate the regression parameter and the unknown residual distribution function. Asymptotic properties, including the uniform consistency and weak convergence, are established for the proposed estimators. Simulation studies demonstrate that the proposed procedure works well under various censoring schemes and outperforms the inverse-probability weighting method in terms of accuracy and efficiency. The method is applied to the HIV/AIDS study.

MSC:

62N02 Estimation in survival analysis and censored data
62G05 Nonparametric estimation
62G20 Asymptotic properties of nonparametric inference
62N01 Censored data models
62P10 Applications of statistics to biology and medical sciences; meta analysis

Software:

icenReg
Full Text: DOI

References:

[1] Anderson-Bergman, C., icenReg: Regression models for interval censored data in R, Journal of Statistical Software, 81, 12, 1-23 (2017)
[2] Buckley, J.; James, I., Linear regression with censored data, Biometrika, 66, 3, 429-436 (1979) · Zbl 0425.62051
[3] Cai, T.; Cheng, S., Semiparametric regression analysis for doubly censored data, Biometrika, 91, 2, 277-290 (2004) · Zbl 1081.62079
[4] Chang, M. N., Weak convergence of a self-consistent estimator of the survival function with doubly censored data, The Annals of Statistics, 18, 1, 391-404 (1990) · Zbl 0706.62044
[5] Choi, S.; Huang, X., Efficient inferences for linear transformation models with doubly censored data, Communications in Statistics-Theory and Methods, 1-13 (2020)
[6] Gao, F.; Zeng, D.; Lin, D. Y., Semiparametric estimation of the accelerated failure time model with partly interval-censored data, Biometrics, 73, 1161-1168 (2017) · Zbl 1405.62129
[7] Gehan, E. A., A generalized two-sample Wilcoxon test for doubly censored data, Biometrika, 52, 650-653 (1965) · Zbl 0142.15803
[8] Groeneboom, P.; Wellner, J. A., Information Bounds and Nonparametric Maximum Likelihood Estimation, vol. 19 (1992), Springer: Springer New York · Zbl 0757.62017
[9] Gu, M.; Zhang, C. H., Asymptotic properties of self-consistent estimators based on doubly censored data, The Annals of Statistics, 21, 611-624 (1993) · Zbl 0788.62029
[10] Huang, J., Efficient estimation for the proportional hazards model with interval censoring, The Annals of Statistics, 24, 2, 540-568 (1996) · Zbl 0859.62032
[11] Huang, J., Asymptotic properties of nonparametric estimation based on partly interval-censored data, Statistica Sinica, 9, 501-519 (1999) · Zbl 0933.62038
[12] Hughes, J. P., Mixed effects models with censored data with application to HIV RNA levels, Biometrics, 55, 625-629 (1999) · Zbl 1059.62661
[13] Hughes, M. D., Analysis and design issues for studies using censored biomarker measurements with an example of viral load measurements in HIV clinical trials, Statistics in Medicine, 19, 3171-3191 (2000)
[14] Jacqmin-Gadda, H.; Rodolphe, T., Analysis of left-censored longitudinal data with application to viral load in HIV infection, Biostatistics, 1, 4, 355-368 (2000) · Zbl 1096.62507
[15] Ji, S.; Peng, L.; Cheng, Y.; Lai, H., Quantile regression for doubly censored data, Biometrics, 68, 1, 101-112 (2012) · Zbl 1241.62157
[16] Jin, Z.; Lin, D.; Wei, L.; Ying, Z., Rank-based inference for the accelerated failure time model, Biometrika, 90, 2, 341-353 (2003) · Zbl 1034.62103
[17] Jin, Z.; Lin, D.; Ying, Z., On least-squares regression with censored data, Biometrika, 93, 1, 147-161 (2006) · Zbl 1152.62068
[18] Khan, S.; Tamer, E., Inference on endogenously censored regression models using conditional moment inequalities, Journal of Econometrics, 152, 2, 104-119 (2009) · Zbl 1431.62639
[19] Kim, Y.; Kim, B.; Jang, W., Asymptotic properties of the maximum likelihood estimator for the proportional hazards model with doubly censored data, Journal of Multivariate Analysis, 101, 6, 1339-1351 (2010) · Zbl 1186.62121
[20] Kim, Y.; Kim, J.; Jang, W., An EM algorithm for the proportional hazards model with doubly censored data, Computational Statistics & Data Analysis, 57, 1, 41-51 (2013) · Zbl 1365.62373
[21] Lai, T. L.; Ying, Z., Estimating a distribution function with truncated and censored data, The Annals of Statistics, 417-442 (1991) · Zbl 0741.62037
[22] Li, S.; Hu, T.; Tong, T.; Sun, J., Semiparametric regression analysis of multivariate doubly censored data, Statistical Modelling, 20, 5, 502-526 (2020) · Zbl 07290039
[23] Li, S.; Hu, T.; Wang, P.; Sun, J., A class of semiparametric transformation models for doubly censored failure time data, Scandinavian Journal of Statistics, 45, 3, 682-698 (2018) · Zbl 1409.62192
[24] Little, R. J.A.; Rubin, D. B., Statistical Analysis with Missing Data (2002), Wiley: Wiley New York · Zbl 1011.62004
[25] Ren, J. J.; Gu, M., Regression M-estimators with doubly censored data, The Annals of Statistics, 25, 6, 2638-2664 (1997) · Zbl 0907.62045
[26] Ren, J. J.; Peer, P. G., A study on effectiveness of screening mammograms, International Journal of Epidemiology, 29, 5, 803-806 (2000)
[27] Shen, P. S.; Chen, C. M., Aalen’s linear model for doubly censored data, Statistics, 52, 6, 1328-1343 (2018) · Zbl 1408.62163
[28] Su, Y. R.; Wang, J. L., Semiparametric efficient estimation for shared-frailty models with doubly-censored clustered data, The Annals of Statistics, 44, 3, 1298-1331 (2016) · Zbl 1341.62285
[29] Swenson, L.; Cobb, B.; Geretti, A.; Harrigan, P.; Poljak, M.; Seguin-Devaux, C.; Verhofstede, C.; Wirden, M.; Amendola, A.; Boni, J.; Bourlet, T.; Huder, J.; Karasi, J.; Lepej, S.; Lunar, M.; Mukabayire, O.; Schuurman, R.; Tomazic, J.; Laethem, K. V.; Vandekerckhove, L.; Wensing, A., Comparative performances of hiv-1 rna load assays at low viral load levels: results of an international collaboration, Journal of Clinical Microbiology, 52, 2, 517-523 (2014)
[30] Tian, L.; Cai, T., On the accelerated failure time model for current status and interval censored data, Biometrika, 93, 2, 329-342 (2006) · Zbl 1153.62362
[31] Tsiatis, A. A., Estimating regression parameters using linear rank tests for censored data, The Annals of Statistics, 18, 1, 354-372 (1990) · Zbl 0701.62051
[32] Turnbull, B. W., Nonparametric estimation of a survivorship function with doubly censored data, Journal of the American Statistical Association, 69, 345, 169-173 (1974) · Zbl 0281.62044
[33] Turnbull, B. W., The empirical distribution function with arbitrarily grouped, censored and truncated data, Journal of the Royal Statistical Society: Series B, 38, 3, 290-295 (1976) · Zbl 0343.62033
[34] Wei, L. J.; Ying, Z.; Lin, D., Linear regression analysis of censored survival data based on rank tests, Biometrika, 77, 4, 845-851 (1990)
[35] Wellner, J. A.; Zhan, Y., A hybrid algorithm for computation of the nonparametric maximum likelihood estimator from censored data, Journal of the American Statistical Association, 92, 439, 945-959 (1997) · Zbl 0889.62026
[36] Zeng, D.; Mao, L.; Lin, D., Maximum likelihood estimation for semiparametric transformation models with interval-censored data, Biometrika, 103, 2, 253-271 (2016) · Zbl 1499.62419
[37] Zhang, C. H.; Li, X., Linear regression with doubly censored data, The Annals of Statistics, 24, 6, 2720-2743 (1996) · Zbl 0898.62042
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