Summary: With the Bondi-Metzner-Sachs (BMS) group in general relativity as the main motivation and example, a theorem is proved which may be described as follows. Let \(G\) be a complex semisimple, connected and simply connected Lie group with compact real form \(K\), and let \(A\) be a metrizable, complete and locally convex real topological vector space on which there is a continuous \(G\) action. Consider the semidirect product topological group \(G\times_sA\) (which is, in general, infinite-dimensional) constructed naturally out of \(G\) and \(A\). If the set of equivalence classes of irreducible representations of \(K\) in \(A\) satisfies certain hypotheses, then the second cohomology group of \(G\times_sA\) in the sense of continuous group cohomology is trivial. When \(G=SL(2,C)\) and \(A\) is an appropriate function space of real-valued functions of the 2-sphere endowed with a specific \(G\) action (e.g. \(A\) may consist of \(C^k\), \(k\geq 3\), real-valued functions defined on the 2-sphere), the semidirect product group is the universal cover of the BMS group. The theorem implies the existence of lifting of the projective unitary representations of the BMS group to the linear unitary representations of its universal cover. In the quantum context when we consider massless quantum fields at null infinity of a non-stationary, asymptotically Minkowski space-time, in place of the projective unitary representations of the BMS group, there is no loss of generality in considering the linear unitary representations of its universal cover instead.