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Oncology nursing

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Chemotherapy drugs

Platinum Analogs: Cisplatin, Carboplatin, OxaliplatinOverview Mechanism • The platinum analogs do not possess an alkyl group but have the same general effect as the alkylating agents: they form lethal cross-links in DNA, so we lump them in with the alkylating agents. Side Effects • Cisplatin can cause nephrotoxicity and ototoxicity. • Carboplatin can cause myelosuppression. • Oxaliplatin can cause peripheral neuropathy.Mechanism Alkylation • The alkylating agents comprise a large group of a…

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