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<div class="skin-invert-image">
{{Annotated image 4
| image       = Estradiol metabolism structures.svg
| image-width = 485
| width       = 485
| height      = 400
| image-left  = 0
| image-top   = 0
| link        = 
| align       = {{{align|center}}}
| caption     = {{{caption|'''Description:''' The [[metabolic pathway]]s involved in the [[metabolism]] of {{No selflink|estradiol}} and other [[natural product|natural]] {{No selflink|estrogen}}s (e.g., {{No selflink|estrone}}, {{No selflink|estriol}}) in humans. In addition to the [[biotransformation|metabolic transformation]]s shown in the diagram, [[conjugation (biochemistry)|conjugation]] (e.g., [[sulfation]] and [[glucuronidation]]) occurs in the case of estradiol and [[metabolite]]s of estradiol that have one or more available [[hydroxyl group|hydroxyl]] (–OH) [[functional group|group]]s. '''Sources:''' <noinclude><ref name="The Menopause">{{cite book | veditors=Buchsbaum HJ | title=The Menopause (Clinical Perspectives in Obstetrics and Gynecology) | date=2012 | publisher=Springer Science & Business Media | location=New York, NY | isbn=9781461255253 | page=64 | url=https://books.google.com/books?id=z0LuBwAAQBAJ&pg=PA64%7Cdate=6}}</ref><ref name="Pharmacology of estrogens and progestogens">{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric : The Journal of the International Menopause Society | volume = 8 Suppl 1 | pages = 3–63 | date = August 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 }}</ref><ref name="Dorfman1961">{{cite book|title=Radioactive Isotopes in Physiology Diagnostics and Therapy|last1=Dorfman|first1=Ralph I.|chapter=Steroid Hormone Metabolism|year=1961|pages=1223–1241|doi=10.1007/978-3-642-49761-2_39|isbn=978-3-642-49477-2 }}</ref><ref name="Estrone sulfotransferase">{{cite website|title=EC 2.4.1.17&nbsp;– glucuronosyltransferase and Organism(s) Homo sapiens|url=https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.17&Suchword=estrone&reference=&UniProtAcc=&organism%5B%5D=Homo+sapiens|website=BRENDA|publisher=Technische Universität Braunschweig|access-date=10 August 2018|date=January 2018}}</ref></noinclude><includeonly>See template page.</includeonly>}}}

| alt         = Graphic of the metabolic pathways of estradiol in humans
| header      = {{Navbar|Estradiol metabolism|mini=y}} {{{header|[[Metabolic pathway]]s of {{no selflink|estradiol}} in humans}}}
| header_background = aliceblue
| annot-font-size = 13
| annotations =


<!-- Top compound row: left to right -->
{{Annotation|40|68|<!--
-->{{if pagename
   |Estradiol='''Estradiol'''
   |Pharmacology of estradiol='''[[Estradiol]]'''
   |Estradiol (medication)='''[[Estradiol]]'''
   |Estrogen='''[[Estradiol]]'''
   |Estrogen (medication)='''[[Estradiol]]'''
   |other=[[Estradiol]]
   }}
}}
{{Annotation|186|68|<!--
-->{{if pagename
   |Estrone sulfate='''Estrone sulfate'''
   |Estrone sulfate (medication)='''[[Estrone sulfate]]'''
   |other=[[Estrone sulfate]]
   }}
}}
{{Annotation|338|83|<!--
-->{{if pagename
   |Estrone glucuronide='''Estrone glucuronide'''
   |other=[[Estrone glucuronide]]
   }}
}}



<!-- 2nd compound row: left to right -->
{{Annotation|10|180|<!--
-->{{if pagename
   |2-Hydroxyestrone='''2-Hydroxyestrone'''
   |other=[[2-Hydroxyestrone]]
   }}
}}
{{Annotation|210|180|<!--
-->{{if pagename
   |Estrone='''Estrone'''
   |Estrone (medication)='''[[Estrone]]'''
   |Estrogen='''[[Estrone]]'''
   |Estrogen (medication)='''[[Estrone]]'''
   |other=[[Estrone]]
   }}
}}
{{Annotation|365|186|<!--
-->{{if pagename
   |4-Hydroxyestrone='''4-Hydroxyestrone'''
   |other=[[4-Hydroxyestrone]]
   }}
}}



<!-- 3rd compound row: left to right -->
{{Annotation|10|280|<!--
-->{{if pagename
   |2-Methoxyestrone='''2-Methoxyestrone'''
   |other=[[2-Methoxyestrone]]
   }}
}}
{{Annotation|180|280|<!--
-->{{if pagename
   |16α-Hydroxyestrone='''16α-Hydroxyestrone'''
   |other=[[16α-Hydroxyestrone]]
   }}
}}
{{Annotation|365|295|<!--
-->{{if pagename
   |4-Methoxyestrone='''4-Methoxyestrone'''
   |other=[[4-Methoxyestrone]]
   }}
}}



<!-- Bottom compound row: left to right -->
{{Annotation|25|384|<!--
-->{{if pagename
   |17-Epiestriol='''17-Epiestriol'''
   |other=[[17-Epiestriol]]
   }}
}}
{{Annotation|210|384|<!--
-->{{if pagename
   |Estriol='''Estriol'''
   |Estriol (medication)='''[[Estriol]]'''
   |Estrogen='''[[Estriol]]'''
   |Estrogen (medication)='''[[Estriol]]'''
   |other=[[Estriol]]
   }}
}}
{{Annotation|375|384|<!--
-->{{if pagename
   |16-Epiestriol='''16-Epiestriol'''
   |other=[[16-Epiestriol]]
   }}
}}



<!-- Enzyme labels - top -->

<!-- Estradiol ←→ Estrone -->
{{Annotation|150|84|[[17β-Hydroxysteroid dehydrogenase#Overview|<span style="color:DeepSkyBlue">17β-HSD</span>]]|font-size=12|text-align=left}}
<!-- Estrone → Estrone sulfate -->
{{Annotation|192|100|[[Estrone sulfotransferase#Types|<span style="color:DeepSkyBlue">EST</span>]]|font-size=12|text-align=right}}
<!-- Estrone sulfate → Estrone -->
{{Annotation|225|100|[[Steroid sulfatase|<span style="color:DeepSkyBlue">STS</span>]]|font-size=12}}
<!-- Estrone → Estrone glucuronide -->
{{Annotation|272|76|[[UGT1A3|<span style="color:DeepSkyBlue">UGT1A3</span>]]<br />[[UGT1A9|<span style="color:DeepSkyBlue">UGT1A9</span>]]|font-size=12}}



<!-- Enzyme labels - middle-top -->

<!-- Estrone → 2-Hydroxyestrone -->
{{Annotation|130|134|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12}}
<!-- Estrone → 4-Hydroxyestrone -->
{{Annotation|296|134|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12}}



<!-- Enzyme labels - middle-bottom -->

<!-- 2-Hydroxyestrone → 2-Methoxyestrone -->
{{Annotation|16|206|[[Catechol-O-methyltransferase|<span style="color:DeepSkyBlue">COMT</span>]]|font-size=12|text-align=right}}
<!-- Estrone → 16α-Hydroxyestrone        -->
{{Annotation|228|198|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12|text-align=right}}
<!-- 4-Hydroxyestrone → 4-Methoxyestrone -->
{{Annotation|364|206|[[Catechol-O-methyltransferase|<span style="color:DeepSkyBlue">COMT</span>]]|font-size=12|text-align=right}}



<!-- Enzyme labels - bottom -->

<!-- 16α-Hydroxyestrone → 17-Epiestriol -->
{{Annotation|128|298|unidentified|font-size=12|text-align=left}}
<!-- 16α-Hydroxyestrone → Estriol       -->
{{Annotation|226|300|[[17β-Hydroxysteroid dehydrogenase|<span style="color:DeepSkyBlue">17β-HSD</span>]]|font-size=12}}
<!-- 16α-Hydroxyestrone → 16-Epiestriol -->
{{Annotation|296|298|unidentified|font-size=12|text-align=right}}

}}
</div>
<noinclude>{{Documentation}}</noinclude>

Pages transcluded onto the current version of this page (help):

Estradiol (edit)
Estriol (edit)
Estrogen (edit)
Estrone (edit)
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