LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain (Q28539803)

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scientific article (publication date: 2014)

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English	LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain	scientific article (publication date: 2014)

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24941071%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain (English)

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20 March 2020

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neuropathic pain

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Luis Eduardo Menezes Quintas

7

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20 March 2020

8

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20 March 2020

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Cleverton K F Lima

1

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20 March 2020

Rafael M Silva

2

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20 March 2020

Renata B Lacerda

3

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20 March 2020

Bruna L R Santos

4

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20 March 2020

Rafaela V Silva

5

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20 March 2020

Luciana S Amaral

6

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20 March 2020

Eliezer J Barreiro

9

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20 March 2020

Marília Z P Guimaraes

10

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20 March 2020

Ana L P Miranda

11

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20 March 2020

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publication date

18 June 2014

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20 March 2020

1 reference

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20 March 2020

9

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20 March 2020

6

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20 March 2020

e99510

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20 March 2020

copyright license

Creative Commons Attribution 4.0 International

18 June 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway

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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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19 March 2017

The capsaicin receptor: a heat-activated ion channel in the pain pathway

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19 March 2017

The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines

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29 September 2017

LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4062389

29 September 2017

TNF-alpha and neuropathic pain--a review

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29 September 2017

Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain

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29 September 2017

Transient receptor potential vanilloid 1 agonists as candidates for anti-inflammatory and immunomodulatory agents.

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29 September 2017

Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain

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29 September 2017

Cytokine and chemokine regulation of sensory neuron function.

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29 September 2017

Targeting innate immunity protein kinase signalling in inflammation

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29 September 2017

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

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29 September 2017

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

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Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes

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Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

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29 September 2017

Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats

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29 September 2017

The neuropathic pain triad: neurons, immune cells and glia

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29 September 2017

Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes

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29 September 2017

A cascade of cytokines mediates mechanical inflammatory hypernociception in mice.

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29 September 2017

The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

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Attenuation of thermal nociception and hyperalgesia by VR1 blockers

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Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization

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A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

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based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve

1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24941071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0099510

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Consolidated OpenCitations Corpus – April 2017

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20 March 2020

2014PLoSO...999510L

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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20 March 2020

PubMed publication ID

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20 March 2020

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