Smad3 knockout mice exhibit impaired intestinal mucosal healing (Q37677420)

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scientific article published on 18 August 2008

Language	Label	Description	Also known as
English	Smad3 knockout mice exhibit impaired intestinal mucosal healing	scientific article published on 18 August 2008

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Smad3 knockout mice exhibit impaired intestinal mucosal healing (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

0 references

author name string

Cheri R Owen

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Lisi Yuan

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Marc D Basson

3

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

publication date

18 August 2008

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Laboratory Investigation

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

88

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1101-1109

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Focal adhesion kinase protein levels in gut epithelial motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Smad3 knock-out mice as a useful model to study intestinal fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Specificity and versatility in tgf-beta signaling through Smads

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Cellular and molecular mechanisms of the epithelial repair in IBD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

HST-1/FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Transforming growth factor beta signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

How cells read TGF-beta signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Transforming growth factor-beta 3 is required for secondary palate fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

23 August 2017

Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

14 September 2017

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

14 September 2017

RNA interference reveals a differential role of FAK and Pyk2 in cell migration, leading edge formation and increase in focal adhesions induced by LPA in intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

14 September 2017

Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

14 September 2017

Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

28 September 2017

Differential glucocorticoid effects on repair mechanisms and NF-kappaB activity in the intestinal epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

28 September 2017

Hepatocyte growth factor accelerates restitution of intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

28 September 2017

Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

Restitution at the cellular level: regulation of the migrating phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

"Healed" experimental gastric ulcers remain histologically and ultrastructurally abnormal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

Colonic motor activity in acute colitis in conscious dogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

25 June 2018

Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Full-thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock-out mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Reduction of Smad3 accelerates re-epithelialization in a murine model of colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Molecular mechanisms of ulcer healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

Alterations of transforming growth factor-beta 1 receptor type II occur in ulcerative colitis-associated carcinomas, sporadic colorectal neoplasms, and esophageal carcinomas, but not in gastric neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3971647

1 September 2018

TGF-beta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defect in colonic smooth muscle contraction in patients with ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 2 enhances intestinal epithelial restitution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2 modulates intestinal epithelial cell function in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen sulfide enhances ulcer healing in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Caco-2 intestinal epithelial motility is associated with tyrosine kinase and cytoskeletal focal adhesion kinase signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transforming growth factor beta 1 receptor type II mutation in ulcerative colitis-associated neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of inflammatory mediators in colonic smooth muscle function in ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation of MAP (Erk-1 and -2) kinases to cell nuclei and activation of c-fos gene during healing of experimental gastric ulcers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the specificity of altered muscle function in experimental colitis in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18711354

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LABINVEST.2008.77

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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release_adaxfnq5lng5por33vflan74ge

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https://api.fatcat.wiki/v0/release/adaxfnq5lng5por33vflan74ge

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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