Id family of helix-loop-helix proteins in cancer (Q28262992)

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31 December 2019

review article

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title

Id family of helix-loop-helix proteins in cancer (English)

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31 December 2019

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31 December 2019

Jonathan Perk

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31 December 2019

Robert Benezra

series ordinal

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31 December 2019

language of work or name

English

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publication date

1 August 2005

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31 December 2019

published in

Nature Reviews Cancer

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31 December 2019

volume

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31 December 2019

issue

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31 December 2019

page(s)

603-614

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Id proteins in development, cell cycle and cancer

31 December 2019

cites work

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Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

21 April 2017

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Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

21 April 2017

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Id genes and proteins as promising targets in cancer therapy

21 April 2017

1 reference

Expression of Id2 and Id3 mRNA in human lymphocytes

21 April 2017

1 reference

Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells

21 April 2017

1 reference

Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells

21 April 2017

1 reference

The retinoblastoma protein and cell cycle control

21 April 2017

1 reference

Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast

21 April 2017

1 reference

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

21 April 2017

1 reference

Principles of tumor suppression

21 April 2017

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The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice

21 April 2017

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Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse

21 April 2017

1 reference

Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach

21 April 2017

1 reference

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

21 April 2017

1 reference

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 April 2017

1 reference

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

21 April 2017

1 reference

TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice

21 April 2017

1 reference

Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans

21 April 2017

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Id4 regulates neural progenitor proliferation and differentiation in vivo

21 April 2017

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Id4 is required for the correct timing of neural differentiation

21 April 2017

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Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

21 April 2017

1 reference

Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation

21 April 2017

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The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP

21 April 2017

1 reference

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 April 2017

1 reference

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 April 2017

1 reference

Role of Id family proteins in growth control

21 April 2017

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High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice

31 March 2020

1 reference

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

31 March 2020

1 reference

Lactation defect in mice lacking the helix-loop-helix inhibitor Id2

31 March 2020

1 reference

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

31 March 2020

1 reference

Mutation analysis of candidate genes in melanoma-prone families

31 March 2020

1 reference

Decreased expression of the Id3 gene at 1p36.1 in ovarian adenocarcinomas

31 March 2020

1 reference

Expression and significances of Id1 helix-loop-helix protein overexpression in gastric cancer

31 March 2020

1 reference

Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors

31 March 2020

1 reference

Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer

31 March 2020

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Utilization of bone marrow-derived endothelial cell precursors in spontaneous prostate tumors varies with tumor grade

31 March 2020

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Over expression of ID-1 in prostate cancer

31 March 2020

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Identification of genes that are regulated transcriptionally by Myc in childhood tumors

31 March 2020

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ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

31 March 2020

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Effect of 20-epi-1alpha,25-dihydroxyvitamin D3 on the proliferation of human neuroblastoma: role of cell cycle regulators and the Myc-Id2 pathway

31 March 2020

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Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

31 March 2020

1 reference

Expression of Id2 mRNA in neuroblastoma and normal ganglion

31 March 2020

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Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma

31 March 2020

1 reference

Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1.

31 March 2020

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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

31 March 2020

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Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix-loop-helix protein Id1.

31 March 2020

1 reference

Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.

31 March 2020

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Id2 is dispensable for myc-induced lymphomagenesis

31 March 2020

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Id2 is dispensable for Myc-induced epidermal neoplasia.

31 March 2020

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The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

31 March 2020

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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

31 March 2020

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Transactivation of the EGR1 gene contributes to mutant p53 gain of function

31 March 2020

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Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins

31 March 2020

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Inhibition of myeloid differentiation by the helix-loop-helix protein Id

31 March 2020

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Neural crest specification regulated by the helix-loop-helix repressor Id2.

31 March 2020

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Constitutive expression of the Id1 gene impairs mouse B cell development

31 March 2020

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Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.

31 March 2020

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Self-renewal and solid tumor stem cells

31 March 2020

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

31 March 2020

1 reference

Id proteins control growth induction in mammalian cells

31 March 2020

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Coupling of cell growth control and apoptosis functions of Id proteins

31 March 2020

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Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1

31 March 2020

1 reference

Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins

31 March 2020

1 reference

Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation

31 March 2020

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Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells.

31 March 2020

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Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a.

31 March 2020

1 reference

To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors

31 March 2020

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CD40 ligand rescues inhibitor of differentiation 3-mediated G1 arrest induced by anti-IgM in WEHI-231 B lymphoma cells

31 March 2020

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Evidence that helix-loop-helix proteins collaborate with retinoblastoma tumor suppressor protein to regulate cortical neurogenesis

31 March 2020

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Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.

31 March 2020

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Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis

31 March 2020

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A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1.

31 March 2020

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The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers

31 March 2020

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E protein silencing by the leukemogenic AML1-ETO fusion protein

31 March 2020

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AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

31 March 2020

1 reference

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

31 March 2020

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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

31 March 2020

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Forced expression of Id-1 in the adult mouse small intestinal epithelium is associated with development of adenomas

31 March 2020

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Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice

31 March 2020

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Overexpression of the Helix-Loop-Helix protein Id2 blocks T cell development at multiple stages.

31 March 2020

1 reference

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors

31 March 2020

1 reference

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

31 March 2020

1 reference

Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.

31 March 2020

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Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.

31 March 2020

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Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

31 March 2020

1 reference

Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.

31 March 2020

1 reference

Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells

31 March 2020

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Role of Id proteins in embryonic and tumor angiogenesis

31 March 2020

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Inhibitors of differentiation/DNA binding proteins Id1 and Id3 are regulated by statins in endothelial cells

31 March 2020

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Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells

31 March 2020

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Modulation of protein-protein interactions with small organic molecules

31 March 2020

1 reference

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

31 March 2020

1 reference

A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex.

31 March 2020

1 reference

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium.

31 March 2020

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Contribution of bone marrow–derived endothelial cells to human tumor vasculature

31 March 2020

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Integrin β4 signaling promotes tumor angiogenesis

31 March 2020

1 reference

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

31 March 2020

1 reference

Transcriptional profiling identifies Id2 function in dendritic cell development

31 March 2020

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Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene

31 March 2020

1 reference

Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

31 March 2020

1 reference

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis

31 March 2020

1 reference

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage

31 March 2020

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Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene

31 March 2020

1 reference

Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells

31 March 2020

1 reference

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.

31 March 2020

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

31 March 2020

1 reference

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

31 March 2020

1 reference

Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies

31 March 2020

1 reference

Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta

31 March 2020

1 reference

Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma

31 March 2020

1 reference

Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor.

31 March 2020

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Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase.

31 March 2020

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Thymocyte development in early growth response gene 1-deficient mice

31 March 2020

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Genes that mediate breast cancer metastasis to lung

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1673

2 references

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

31 December 2019

1006049482

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16034366%20AND%20SRC:MED&resulttype=core&format=json