Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas (Q58053622)

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scientific article published on 01 May 2010

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English	Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas	scientific article published on 01 May 2010

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19 January 2020

Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas (English)

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19 January 2020

Suet-feung Chin

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19 January 2020

Felip Vilardell

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

Gabriel Capella

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19 January 2020

Joel K Greenson

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Joel K Greenson

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19 January 2020

Antònia Obrador-Hevia

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19 January 2020

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Sara González

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19 January 2020

Jonathan Rees

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19 January 2020

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1 May 2010

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19 January 2020

Journal of Pathology

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

The genetics of FAP and FAP-like syndromes

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Functional Characterization of the Novel APC N1026S Variant Associated With Attenuated Familial Adenomatous Polyposis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Aberrant crypt foci of the colon as precursors of adenoma and cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

APC mutations are sufficient for the growth of early colorectal adenomas

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

APC and the three-hit hypothesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Transcriptome profile of human colorectal adenomas.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

A two-step model for colon adenoma initiation and progression caused by APC loss

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology

1 reference

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21 January 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Human and mouse oligonucleotide-based array CGH.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Bioconductor: open software development for computational biology and bioinformatics

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Analysis of array CGH data: from signal ratio to gain and loss of DNA regions

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Detection of APC gene deletions using quantitative multiplex PCR of short fluorescent fragments

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Constitutional high expression of an APC mRNA isoform in a subset of attenuated familial adenomatous polyposis patients.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Identification of c-MYC as a target of the APC pathway

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Myc deletion rescues Apc deficiency in the small intestine

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

The Wnt antagonist sFRP1 in colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Chromosomal instability in MYH- and APC-mutant adenomatous polyps

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

Small changes in expression affect predisposition to tumorigenesis

1 reference

https://api.crossref.org/works/10.1002%2FPATH.2685

21 January 2018

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10.1002/PATH.2685

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19 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20196079%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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