Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas (Q28592004)

31 January 2017

title

Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas (English)

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Adenomatous polyposis coli protein

31 January 2017

main subject

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GOA release 2020-03-11

S. Colnot

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31 January 2017

T. Decaens

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31 January 2017

M. Niwa-Kawakita

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31 January 2017

C. Godard

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31 January 2017

G. Hamard

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31 January 2017

A. Kahn

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31 January 2017

M. Giovannini

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31 January 2017

C. Perret

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31 January 2017

language of work or name

English

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publication date

7 December 2004

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Proceedings of the National Academy of Sciences of the United States of America

31 January 2017

published in

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31 January 2017

volume

101

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31 January 2017

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31 January 2017

page(s)

17216–17221

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Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis

31 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535370

Identification of c-MYC as a target of the APC pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535370

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535370

Caught up in a Wnt storm: Wnt signaling in cancer

7 April 2017

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Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers

7 April 2017

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Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver.

29 September 2017

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BRCA1: the enigma of tissue-specific tumor development.

29 September 2017

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Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles

29 September 2017

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Hepatocellular carcinoma: diagnosis and treatment

29 September 2017

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Genetics of hepatocellular carcinoma

29 September 2017

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29 September 2017

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

29 September 2017

1 reference

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Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

29 September 2017

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Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

29 September 2017

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Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis

29 September 2017

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Risk of hepatoblastoma in familial adenomatous polyposis

29 September 2017

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Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice.

29 September 2017

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Biallelic inactivation of the APC gene in hepatoblastoma

3 June 2018

1 reference

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Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0404761101

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=535370

Immunohistochemical detection of aberrant p53 expression in hepatocellular carcinoma: correlation with cell proliferative activity indices, including mitotic index and MIB-1 immunostaining

27 November 2018

1 reference

12 December 2020

Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma

1 reference

12 December 2020

Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli

1 reference

12 December 2020

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin

1 reference

12 December 2020

Hepatocellular carcinoma in children associated with Gardner syndrome or familial adenomatous polyposis

1 reference

12 December 2020

Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations

1 reference

12 December 2020

Immunohistochemical studies on the expression of P-glycoprotein and p53 in relation to histological differentiation and cell proliferation in hepatocellular carcinoma

1 reference

12 December 2020

Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice

1 reference

12 December 2020

The multiple functions of tumour suppressors: it's all in APC

1 reference

12 December 2020

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0404761101

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ADS bibcode

2004PNAS..10117216C

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