Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts (Q36970922)

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scientific article published on January 2014

Language	Label	Description	Also known as
English	Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts	scientific article published on January 2014

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scholarly article

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1 March 2020

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts (English)

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1 March 2020

5

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1 March 2020

author name string

Laura A Johnson

1

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1 March 2020

Eva S Rodansky

2

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1 March 2020

Andrew J Haak

3

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1 March 2020

Scott D Larsen

4

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1 March 2020

Peter D R Higgins

6

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1 March 2020

publication date

1 January 2014

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1 March 2020

Inflammatory Bowel Diseases

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1 March 2020

20

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1 March 2020

1

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1 March 2020

154-165

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1 March 2020

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

1 reference

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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

1 reference

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CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to substrate stiffness in colonic myofibroblasts.

1 reference

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29 September 2017

Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction

1 reference

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Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase

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Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β.

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Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells

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Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

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Excerpts from the US Renal Data System 2009 Annual Data Report

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Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

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Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

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29 September 2017

The myofibroblast: paradigm for a mechanically active cell

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Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

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29 September 2017

Growth control by intracellular tension and extracellular stiffness

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Mechanisms of fibrogenesis

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling

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29 September 2017

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

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29 September 2017

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

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Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

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Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.

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Mechanoregulation of gene expression in fibroblasts

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29 September 2017

Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression

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Actin dynamics control SRF activity by regulation of its coactivator MAL

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1 reference

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12 December 2020

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Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24280883

12 December 2020

based on heuristic

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Medical Therapy of Crohn's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24280883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1

1 reference

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Identifiers

10.1097/01.MIB.0000437615.98881.31

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24280883%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24280883%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24280883%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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