Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Hypertriglyceridemia- from Innocent Bystander to Independent Cardiovascular Risk Factor in Younger Prehypertensives

Josipa Josipovic

^* ,

Ana Jelakovic

Bernardica Valent Moric

Version 1 : Received: 6 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (08:24:34 CEST)

How to cite: Josipovic, J.; Jelakovic, A.; Valent Moric, B.; Prelevic, V.; Mirosevic, G.; Matijaca, H.; Ivanko, I.; Bulj, N.; Gabric, I. D.; Jelakovic, B. Hypertriglyceridemia- from Innocent Bystander to Independent Cardiovascular Risk Factor in Younger Prehypertensives. Preprints 2024, 2024060451. https://doi.org/10.20944/preprints202406.0451.v1 Josipovic, J.; Jelakovic, A.; Valent Moric, B.; Prelevic, V.; Mirosevic, G.; Matijaca, H.; Ivanko, I.; Bulj, N.; Gabric, I. D.; Jelakovic, B. Hypertriglyceridemia- from Innocent Bystander to Independent Cardiovascular Risk Factor in Younger Prehypertensives. Preprints 2024, 2024060451. https://doi.org/10.20944/preprints202406.0451.v1

Abstract

Background: Population studies have shown that prehypertension is associated with adverse cardiometabolic risk profile even among apparently healthy populations. Although associations between serum triglyceride (TG) concentrations and the risk of atherosclerotic cardiovascular disease have been reported, there are lack of data on the association of hypertriglyceridemia with cardiovascular risk (CVR) in a low risk prehypertensive population. Aim: Our aim was to analyze the cardiorenometabolic characteristics of prehypertensives (PHT) compared to normotensives (NT) and untreated hypertensives (HT) and its associations with CVR. Materials and methods: In our cross-sectional study we included 323 apparently healthy untreated subjects 18-45 years who underwent basic anthropometric and standardized blood pressure measurement, fasting blood sampling, spot urine collection and transthoracic echocardiogram. Results: Higher BMI, waist circumference, HOMA-IR, LDL-cholesterol, TG, uric acid and LVMI contribute to higher CVR in PHT compared to true NT (p

Keywords

prehypertension; hypertriglyceridemia; uromodulin; cardiovascular risk

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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