Version 1
: Received: 27 May 2024 / Approved: 27 May 2024 / Online: 27 May 2024 (10:27:42 CEST)
How to cite:
Oshchepkov, M. S.; Kovalenko, L.; Kalistratova, A.; Sherstyanykh, G.; Gorbacheva, E.; Antonov, A.; Ustinova, K.; Khadour, N.; Akimov, A. M. Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents. Preprints2024, 2024051732. https://doi.org/10.20944/preprints202405.1732.v1
Oshchepkov, M. S.; Kovalenko, L.; Kalistratova, A.; Sherstyanykh, G.; Gorbacheva, E.; Antonov, A.; Ustinova, K.; Khadour, N.; Akimov, A. M. Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents. Preprints 2024, 2024051732. https://doi.org/10.20944/preprints202405.1732.v1
Oshchepkov, M. S.; Kovalenko, L.; Kalistratova, A.; Sherstyanykh, G.; Gorbacheva, E.; Antonov, A.; Ustinova, K.; Khadour, N.; Akimov, A. M. Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents. Preprints2024, 2024051732. https://doi.org/10.20944/preprints202405.1732.v1
APA Style
Oshchepkov, M. S., Kovalenko, L., Kalistratova, A., Sherstyanykh, G., Gorbacheva, E., Antonov, A., Ustinova, K., Khadour, N., & Akimov, A. M. (2024). Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents. Preprints. https://doi.org/10.20944/preprints202405.1732.v1
Chicago/Turabian Style
Oshchepkov, M. S., Nisreen Khadour and and Mikhail Akimov. 2024 "Anti-Proliferative and Cytoprotective Activity of Ethylenediurea Derivatives with Alkyl and Oxygen-containing Groups as Substituents" Preprints. https://doi.org/10.20944/preprints202405.1732.v1
Abstract
Natural cytokinins are a promising group of cytoprotective and anti-tumor agents. In this research, we synthesized a set of novel cytokinin analogs with alkyl substituents at various positions of the aromatic moiety, as well as with oxygen-containing groups, and tested their antiproliferative activity in MDA-MB-231, A-375, and U-87 MG cell lines, and cytoprotective properties in H2O2 and CoCl2 models. Two amino-linked compounds were anti-proliferative with the ability to act synergistically with doxorubicin, and two carbamate-based ones were cytoprotective. According to the molecular docking data, anti-proliferation was based on the A2AR and APRT inhibition and cytoprotection on the CDK2 inhibition. The obtained results are promising for the development of novel anti-cancer therapeutics.
Chemistry and Materials Science, Medicinal Chemistry
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