PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV
Version 1
: Received: 17 October 2023 / Approved: 17 October 2023 / Online: 17 October 2023 (11:46:43 CEST)
How to cite:
Aboagye, J. O.; Ayanful-Torgby, R.; Zhou, L.; Wormenor, P.; Ganu, V.; Tachi, K.; Attoh, B. N. A.; Mensah, M.; Kuuguu, T.; Kyei, G. B.; Paintsil, E. Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV. Preprints2023, 2023101076. https://doi.org/10.20944/preprints202310.1076.v1
Aboagye, J. O.; Ayanful-Torgby, R.; Zhou, L.; Wormenor, P.; Ganu, V.; Tachi, K.; Attoh, B. N. A.; Mensah, M.; Kuuguu, T.; Kyei, G. B.; Paintsil, E. Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV. Preprints 2023, 2023101076. https://doi.org/10.20944/preprints202310.1076.v1
Aboagye, J. O.; Ayanful-Torgby, R.; Zhou, L.; Wormenor, P.; Ganu, V.; Tachi, K.; Attoh, B. N. A.; Mensah, M.; Kuuguu, T.; Kyei, G. B.; Paintsil, E. Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV. Preprints2023, 2023101076. https://doi.org/10.20944/preprints202310.1076.v1
APA Style
Aboagye, J. O., Ayanful-Torgby, R., Zhou, L., Wormenor, P., Ganu, V., Tachi, K., Attoh, B. N. A., Mensah, M., Kuuguu, T., Kyei, G. B., & Paintsil, E. (2023). Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV. Preprints. https://doi.org/10.20944/preprints202310.1076.v1
Chicago/Turabian Style
Aboagye, J. O., George Boateng Kyei and Elijah Paintsil. 2023 "Concordance of Cancer-Associated Cytokines and Mitochondrial DNA Deletion Mutations between Individuals with Hepatocellular Carcinoma and People Living with HIV" Preprints. https://doi.org/10.20944/preprints202310.1076.v1
Abstract
Hepatocellular carcinoma (HCC) is a non-AIDS-defining cancer closely tied to the chronic HIV infection and associated with the release of inflammatory cytokines, immune system dysfunction, and genetic alterations within mitochondria. However, our understanding of how these factors contribute to HCC risk in PLWH is limited. The objective of the study was to ascertain the differential secretion of cytokines and mitochondria DNA (mtDNA) deletion in PLWH, and individuals diagnosed with HCC without HIV. A cross-sectional study was conducted with PLWH and HCC participants from the Korle-Bu Teaching Hospital. Plasma and peripheral blood mononuclear cells (PBMCs) were isolated from whole blood. The plasma samples were used to measure cytokines using ELISA and Luminex techniques. We determined mtDNA deletions from PBMCs. We found that the secretion of the cytokines TGF-β, FGF-2, IL-8, TNF-α, VEGF, and RANTES implicated in the pre-cancer, initiation, and early stages of HCC were similar in PLWH compared to HCC participants without HIV. PBMCs of PLWH exhibited high mtDNA deletion (60%) comparable to HCC participants without HIV (64%). These findings underscore the underlying risks associated with HCC development in PLWH. There is a need for HCC surveillance among PLWH and these cytokines could be used as biomarkers.
Keywords
Hepatocellular carcinoma (HCC); Human immunodeficiency virus (HIV); hepatitis; inflammatory cytokines; mitochondria DNA deletion
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.