Trichophyton indotineae and other terbinafine-resistant dermatophytes in North America
- PMID: 38014979
- PMCID: PMC10729746
- DOI: 10.1128/jcm.00903-23
Trichophyton indotineae and other terbinafine-resistant dermatophytes in North America
Abstract
Dermatophyte infections (a.k.a. ringworm, tinea) affect an estimated 20%-25% of the world's population. In North America, most dermatophytoses are caused by Trichophyton rubrum or Trichophyton mentagrophytes species complexes. Severe and antifungal-resistant dermatophytoses are a growing global public health problem. A new species of the T. mentagrophytes species complex, Trichophyton indotineae, has recently emerged and is notable for the severe infections it causes, its propensity for antifungal resistance, and its global spread. In this issue of the Journal of Clinical Microbiology, C. F. Cañete-Gibas, J. Mele, H. P. Patterson, et al. (J Clin Microbiol 61:e00562-23, 2023, https://doi.org/10.1128/JCM.00562-23) summarize the results of speciation and AFST performed on North American dermatophyte isolates received at a fungal diagnostic reference laboratory. Within their collection, 18.6% of isolates were resistant to terbinafine (a first-line oral antifungal for dermatophytoses), and similar proportions of T. rubrum and T. indotineae demonstrated terbinafine resistance. The authors also found that T. indotineae has been present in North America since at least 2017. These findings highlight the importance of increased surveillance efforts to monitor trends in severe and antifungal-resistant dermatophytoses and the need for antifungal stewardship efforts, the success of which is contingent upon improving laboratory capacity for dermatophyte speciation and AFST.
Conflict of interest statement
The authors declare no conflict of interest.
Comment on
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Terbinafine-Resistant Dermatophytes and the Presence of Trichophyton indotineae in North America.J Clin Microbiol. 2023 Aug 23;61(8):e0056223. doi: 10.1128/jcm.00562-23. Epub 2023 Jul 11. J Clin Microbiol. 2023. PMID: 37432126 Free PMC article.
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