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Pustular Psoriasis

Muneeb Shah  1 , Daifallah M. Al Aboud  2 , Jonathan S. Crane  3 , Sandeep Kumar  4
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
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Pustular Psoriasis

Muneeb Shah et al.
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Excerpt

Pustular psoriasis is a rare, immune-mediated systemic skin disorder characterized by yellowish pustules on an erythematous base with a variety of clinical presentations and distribution patterns. Pustular psoriasis is considered a variant of psoriasis vulgaris. The pustules can be widespread or localized and are characterized by a sterile predominantly neutrophilic infiltrate. Unlike chronic plaque psoriasis (the most common variant of psoriasis vulgaris), lesions of pustular psoriasis are often tender to palpation. Pustular psoriasis can be further subdivided based on the clinical presentation and the location of pustules.

Subtypes of pustular psoriasis include:

  1. Generalized:

    1. von Zumbusch subtype: Diffuse generalized pustular eruption with associated systemic symptoms (fevers, arthralgias, etc.)

    2. Annular subtype: Annular lesions with pustules along the advancing edge.

    3. Exanthematic subtype: Acute pustular eruption without systemic symptoms that resolves after a few days.

    4. Impetigo herpetiformis: Pustular psoriasis occurring during pregnancy.

  2. Localized:

    1. Acrodermatitis continua of Hallopeau: Pustules affecting the fingers, toes, and nail beds.

    2. Palmoplantar psoriasis: Pustules affecting the palms and soles

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Conflict of interest statement

Disclosure: Muneeb Shah declares no relevant financial relationships with ineligible companies.

Disclosure: Daifallah Al Aboud declares no relevant financial relationships with ineligible companies.

Disclosure: Jonathan Crane declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Kumar declares no relevant financial relationships with ineligible companies.

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References

    1. Tsuchida Y, Hayashi R, Ansai O, Nakajima M, Oginezawa M, Kawai T, Yokoyama R, Deguchi T, Hama N, Shinkuma S, Abe R. Generalized pustular psoriasis complicated with bullous pemphigoid. Int J Dermatol. 2019 Mar;58(3):e66-e67. - PubMed
    1. Negrotto L, Correale J. Palmar pustular psoriasis associated with teriflunomide treatment. Mult Scler Relat Disord. 2019 Jan;27:400-402. - PubMed
    1. Epple A, Paffhausen JE, Fink C, Enk A, Sedlaczek O, Haenssle HA. Chronic recurrent multifocal osteomyelitis with psoriatic skin manifestations in a 12-year-old female. Dermatol Pract Concept. 2018 Oct;8(4):297-298. - PMC - PubMed
    1. Madanagobalane S. Secukinumab in Generalized Pustular Psoriasis. Indian Dermatol Online J. 2018 Nov-Dec;9(6):464-466. - PMC - PubMed
    1. Boehner A, Navarini AA, Eyerich K. Generalized pustular psoriasis - a model disease for specific targeted immunotherapy, systematic review. Exp Dermatol. 2018 Oct;27(10):1067-1077. - PubMed

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