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Case Reports
. 2008 May;31(5):295-8.
doi: 10.1157/13119883.

[Acute generalized exanthematous pustulosis induced by omeprazole]

[Article in Spanish]
Oscar Nantes Castillejo  1 , José Manuel Zozaya Urmeneta, Ana Valcayo Peñalba, José María Martínez-Peñuela Virseda
Affiliations
Case Reports

[Acute generalized exanthematous pustulosis induced by omeprazole]

[Article in Spanish]
Oscar Nantes Castillejo et al. Gastroenterol Hepatol. 2008 May.

Abstract

Acute generalized exanthematous pustulosis (AGEP) comprises a group of eruptions characterized by several small sterile pustules over an erythematous-edematous skin. These eruptions are usually drug induced and show some characteristics that suggest an immunologic background. Treatment is based on withdrawal of the drug causing the eruption. Prognosis is generally good and the skin lesions usually resolve in a few days with characteristic postpustular pin-point desquamation. We report three cases of AGEP induced by omeprazole, a drug with a good safety profile. Some adverse cutaneous reactions have been described as secondary effects. However, to our knowledge, no cases of omeprazole-induced AGEP have previously been reported. AGEP related to other proton pump inhibitors is exceptional.

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