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PLCB3

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(Redirected from PLCB3 (gene))
PLCB3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLCB3, phospholipase C beta 3, SMDCD
External IDsOMIM: 600230; MGI: 104778; HomoloGene: 47960; GeneCards: PLCB3; OMA:PLCB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000932
NM_001184883
NM_001316314

NM_001290349
NM_008874

RefSeq (protein)

NP_000923
NP_001171812
NP_001303243

NP_001277278
NP_032900

Location (UCSC)Chr 11: 64.25 – 64.27 MbChr 19: 6.93 – 6.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[5][6]

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

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PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149782Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024960Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81. doi:10.1093/hmg/3.10.1775. PMID 7849701.
  6. ^ "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)".
  7. ^ Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (June 2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.

Further reading

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