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Protein-coding gene in the species Homo sapiens
Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene .[ 5] [ 6]
Function
PNRC1 functions as a coactivator for several nuclear receptors including AR , ERα , ERRα , ERRγ , GR , SF1 , PR , TR , RAR and RXR .[ 7] [ 8] SH3 domain of PNRC1.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000146278 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040128 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta . 1264 (1): 19–22. doi :10.1016/0167-4781(95)00159-e . PMID 7578250 . ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1" .^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)" . Mol. Endocrinol . 14 (7): 986–98. doi :10.1210/mend.14.7.0480 PMID 10894149 . ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif" . Nucleic Acids Res . 29 (19): 3939–48. doi :10.1093/nar/29.19.3939 . PMC 60244 PMID 11574675 .
Further reading
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhou D, Chen B, Ye JJ, Chen S (2004). "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction" . Oncogene . 23 (31): 5394–404. doi :10.1038/sj.onc.1207695 PMID 15122321 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells" . J. Biol. Chem . 274 (32): 22373–9. CiteSeerX 10.1.1.621.2877 doi :10.1074/jbc.274.32.22373 PMID 10428808 . S2CID 15532327 .
External links
