HLA-DQB2

HLA-DQB2
Identifiers
Aliases	HLA-DQB2, HLA-DQB1, HLA-DXB, major histocompatibility complex, class II, DQ beta 2, DQB2
External IDs	OMIM: 615161; GeneCards: HLA-DQB2; OMA:HLA-DQB2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,763,532 bp
RNA expression pattern
	Top expressed in
	lymph node; ; granulocyte; ; skin of abdomen; ; skin of leg; ; appendix; ; upper lobe of left lung; ; monocyte; ; spleen; ; duodenum; ; right lung;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class II receptor activity;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; transport vesicle membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; immune response; T cell receptor signaling pathway; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3120
	n/a
ENSG00000230675; ENSG00000196610; ENSG00000228254; ENSG00000232629; ENSG00000229493;
	ENSG00000228813; ENSG00000226165; ENSG00000224305
	n/a
	P05538
	n/a
	NM_001198858; NM_001300790; NM_182549
	n/a
	NP_001185787; NP_001287719
	n/a
	Wikidata
View/Edit Human

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HLA class II histocompatibility antigen, DX beta chain is a protein that in humans is encoded by the HLA-DQB2 gene.^[3]^[4]

References

^ ^a ^b ^c ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 GRCh38: Ensembl release 89: ENSG00000230675, ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Berdoz J, Tiercy JM, Rollini P, Mach B, Gorski J (May 1989). "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC". Immunogenetics. 29 (4): 241–8. doi:10.1007/BF00717908. PMID 2564844. S2CID 8196719.
^ "Entrez Gene: HLA-DQB2 major histocompatibility complex, class II, DQ beta 2".

Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi:10.4049/jimmunol.144.2.526. PMID 1967269. S2CID 23550626.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. doi:10.4049/jimmunol.141.11.3715. PMID 2846691. S2CID 2607172.
Jonsson AK, Hyldig-Nielsen JJ, Servenius B, et al. (1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes". J. Biol. Chem. 262 (18): 8767–77. doi:10.1016/S0021-9258(18)47482-0. PMID 3036828.
Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research. 2 (3): 163–74. doi:10.1089/aid.1.1986.2.163. PMID 3489470.
Okada K, Boss JM, Prentice H, et al. (1985). "Gene organization of DC and DX subregions of the human major histocompatibility complex". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3410–4. Bibcode:1985PNAS...82.3410O. doi:10.1073/pnas.82.10.3410. PMC 397785. PMID 3858830.
Houlgatte R, Scarmato P, el Marhomy S, et al. (1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. doi:10.4049/jimmunol.152.9.4475. PMID 7512597. S2CID 41283223.
Chirmule N, McCloskey TW, Hu R, et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol.155.2.917. PMID 7541827. S2CID 8911033.
Rowell JF, Stanhope PE, Siliciano RF (1995). "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. doi:10.4049/jimmunol.155.1.473. PMID 7602119. S2CID 19994352.
Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. doi:10.1016/0161-5890(94)90092-2. PMID 8084338.
Chirmule N, Wang XP, Hu R, et al. (1994). "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. doi:10.1006/cimm.1994.1110. PMID 8168144.
Callahan KM, Rowell JF, Soloski MJ, et al. (1993). "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. doi:10.4049/jimmunol.151.6.2928. PMID 8376762. S2CID 1391866.
Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, et al. (1997). "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. doi:10.1074/jbc.272.13.8671. PMID 9079699.
Hsu SH, Robbins FM, Modelo RB, et al. (1998). "Identification of a new DQB1*0613 allele in a family". Tissue Antigens. 50 (6): 685–7. doi:10.1111/j.1399-0039.1997.tb02935.x. PMID 9458130.
Kanazawa S, Okamoto T, Peterlin BM (2000). "Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection". Immunity. 12 (1): 61–70. doi:10.1016/S1074-7613(00)80159-4. PMID 10661406.
Poon DT, Coren LV, Ott DE (2000). "Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging". J. Virol. 74 (8): 3918–23. doi:10.1128/JVI.74.8.3918-3923.2000. PMC 111903. PMID 10729169.

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[refGRCh38Ensembl-1] ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 GRCh38: Ensembl release 89: ENSG00000230675, ENSG00000196610, ENSG00000228254, ENSG00000232629, ENSG00000229493, ENSG00000228813, ENSG00000226165, ENSG00000224305 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2564844-3] Berdoz J, Tiercy JM, Rollini P, Mach B, Gorski J (May 1989). "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC". Immunogenetics. 29 (4): 241–8. doi:10.1007/BF00717908. PMID 2564844. S2CID 8196719.

[entrez-4] "Entrez Gene: HLA-DQB2 major histocompatibility complex, class II, DQ beta 2".

[1]

v t e Major histocompatibility complex classes
MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G
MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5
Other	Human leukocyte antigen Minor histocompatibility antigen Blood transfusion Arrestin Calgranulin Human blood group systems Cell adhesion molecules Cluster of differentiation

References

Further reading