HLA-DOA

HLA-DOA
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4I0P
Identifiers
Aliases	HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDs	OMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,009,591 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,314,208 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; granulocyte; ; spleen; ; gallbladder; ; monocyte; ; blood; ; tonsil; ; upper lobe of left lung; ; right lung;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; thymus; ; morula; ; submandibular gland; ; subcutaneous adipose tissue; ; embryo; ; primary oocyte; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	MHC class II receptor activity; protein binding; MHC class II protein complex binding;
Cellular component	integral component of membrane; lysosomal membrane; endosome; plasma membrane; lysosome; MHC class II protein complex; endosome membrane; membrane;
Biological process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; regulation of T cell differentiation; immune system process; signal transduction; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3111
	15001
ENSG00000204252; ENSG00000230141; ENSG00000232962; ENSG00000235744; ENSG00000231558;
	ENSG00000206292; ENSG00000232957
	ENSMUSG00000024334
	P06340
	n/a
	NM_002119; NM_015851
	NM_008206
	NP_002110
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.^[5]^[6]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.^[6]

References

^ ^a ^b ^c ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024334 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. S2CID 31652916.
^ ^a ^b "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi:10.4049/jimmunol.144.2.526. PMID 1967269.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
Rosen-Bronson S, Long EO (1991). "An unusual form of alternative splicing in the HLA-DNA gene". Immunogenetics. 33 (2): 124–31. doi:10.1007/BF00210826. PMID 1999352. S2CID 23451770.
Jonsson AK, Rask L (1989). "Human class II DNA and DOB genes display low sequence variability". Immunogenetics. 29 (6): 411–3. doi:10.1007/BF00375872. PMID 2499532. S2CID 5481750.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. doi:10.4049/jimmunol.141.11.3715. PMID 2846691.
Inoko H, Ando A, Kimura M, Tsuji K (1985). "Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha". J. Immunol. 135 (3): 2156–9. doi:10.4049/jimmunol.135.3.2156. PMID 2991382.
Trowsdale J, Kelly A (1986). "The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions". EMBO J. 4 (9): 2231–7. doi:10.1002/j.1460-2075.1985.tb03919.x. PMC 554490. PMID 3000765.
Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research. 2 (3): 163–74. doi:10.1089/aid.1.1986.2.163. PMID 3489470.
Houlgatte R, Scarmato P, el Marhomy S, et al. (1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. doi:10.4049/jimmunol.152.9.4475. PMID 7512597.
Chirmule N, McCloskey TW, Hu R, et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol.155.2.917. PMID 7541827.
Rowell JF, Stanhope PE, Siliciano RF (1995). "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. doi:10.4049/jimmunol.155.1.473. PMID 7602119. S2CID 19994352.
Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. doi:10.1016/0161-5890(94)90092-2. PMID 8084338.
Chirmule N, Wang XP, Hu R, et al. (1994). "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. doi:10.1006/cimm.1994.1110. PMID 8168144.
Callahan KM, Rowell JF, Soloski MJ, et al. (1993). "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. doi:10.4049/jimmunol.151.6.2928. PMID 8376762.
Liljedahl M, Kuwana T, Fung-Leung WP, et al. (1996). "HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport". EMBO J. 15 (18): 4817–24. doi:10.1002/j.1460-2075.1996.tb00862.x. PMC 452218. PMID 8890155.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, et al. (1997). "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. doi:10.1074/jbc.272.13.8671. PMID 9079699.
Douek DC, Altmann DM (1997). "HLA-DO is an intracellular class II molecule with distinctive thymic expression". Int. Immunol. 9 (3): 355–64. doi:10.1093/intimm/9.3.355. PMID 9088974.

This immunology article is a stub. You can help Wikipedia by expanding it.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024334 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2370084-5] Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. S2CID 31652916.

[entrez-6] "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

[1]

v t e Major histocompatibility complex classes
MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G
MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5
Other	Human leukocyte antigen Minor histocompatibility antigen Blood transfusion Arrestin Calgranulin Human blood group systems Cell adhesion molecules Cluster of differentiation

References

Further reading