SKF-83959

SKF-83959
IUPAC ime
	6-hloro-7,8-dihidroksi-3-metil-1-(3-metilfenil)-2,3,4,5-tetrahidro-1H-3-benzazepin
Identifikatori
ATC kod	none
PubChem	CID 24278699
ChemSpider	10131933
ChEMBL	CHEMBL520992
Hemijski podaci
Formula	C18H20ClNO2
Molarna masa	317,810 g/mol
	SMILES Br.Clc1c3c(cc(O)c1O)C(c2cccc(c2)C)CN(CC3)C; ;
	InChI InChI=1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H ; Key:FHYWNBUFNGHNCP-UHFFFAOYSA-N ;

SKF-83,959 je sintetički benzazepinski derivat koji se koristi u naučnim istraživanjima. On deluje kao selektivni antagonist D₁ receptor i pun agonist D₅ receptora. On ima visok afinitet za oba receptora, te stimuliše putem D₅ receptora PLC/PI put sekundarnog glasnika bez uticaja na cAMP/AC put, koji je povezan sa D₁ receptorom.^[1]^[2]^[3]^[4]

Reference

^ Jin LQ, Goswami S, Cai G, Zhen X, Friedman E (2003). „SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain”. Journal of Neurochemistry. 85 (2): 378—86. PMID 12675914.
^ Zhen X, Goswami S, Friedman E (2005). „The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959”. Pharmacology, Biochemistry, and Behavior. 80 (4): 597—601. PMID 15820529. doi:10.1016/j.pbb.2005.01.016.
^ Zhang ZJ, Jiang XL, Zhang SE, Hough CJ, Li H, Chen JG, Zhen XC (2005). „The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm”. Neuroscience Letters. 382 (1-2): 134—8. PMID 15911136. doi:10.1016/j.neulet.2005.03.001.
^ Sahu A, Tyeryar KR, Vongtau HO, Sibley DR, Undieh AS (2009). „D5 dopamine receptors are required for dopaminergic activation of phospholipase C”. Molecular Pharmacology. 75 (3): 447—53. PMID 19047479. doi:10.1124/mol.108.053017.