Diadenozin heksafosfatna hidrolaza (formira AMP)
(Preusmjereno sa stranice NUDT10 (gene name))
| Diadenozin heksafosfatna hidrolaza (formira AMP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.60 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diadenozin heksafosfatna hidrolaza (formira AMP) (EC 3.6.1.60, hAps1, NUDT11 (gen), hAps2, NUDT10 (gen)) je enzim sa sistematskim imenom P1,P6-bis(5'-adenozil)heksafosfat nukleotidohidrolaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) P1,P6-bis(5'-adenozil)heksafosfat + H2O adenozin 5'-pentafosfat + AMP
- (2) P1,P5-bis(5'-adenozil)pentafosfat + H2O adenozin 5'-tetrafosfat + AMP
Dvovalentni kation je esencijalan za aktivnost.
- ↑ Leslie, N.R., McLennan, A.G. and Safrany, S.T. (2002). „Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases”. BMC Biochem 3: #20-20. PMID 12121577.
- ↑ Safrany, S.T., Ingram, S.W., Cartwright, J.L., Falck, J.R., McLennan, A.G., Barnes, L.D. and Shears, S.B. (1999). „The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein”. J. Biol. Chem. 274: 21735-21740. PMID 10419486.
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