Folinska kiselina

Folinska kiselina
(IUPAC) ime
	(2S)-2[4-[(2-amino-5-formil-4-okso-5,6,7,8-; tetrahidro-1H-pteridin-6-il)metilamino]; benzoil]amino}pentanedionska kiselina
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	1492-18-8
ATC kod	V03AF03
PubChem	6006
DrugBank	DB00650
ChemSpider	5784
UNII	RPR1R4C0P4
ChEMBL	CHEMBL1679
Hemijski podaci
Formula	C20H23N7O7
Mol. masa	473,44 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1 ; Key: VVIAGPKUTFNRDU-ABLWVSNPSA-N
Farmakokinetički podaci
Bioraspoloživost	zavisno od doze
Vezivanje za proteine plazme	~15%
Poluvreme eliminacije	6,2 sata
Izlučivanje	Urinarno
Farmakoinformacioni podaci
Trudnoća	A(AU) C(US)
Pravni status	℞ Prescription only
Način primene	Intravenozno, oralno

Folinska kiselina (leukovorin) je pomoćni lek koji se koristi u hemoterapiji kancera primenom leka metotreksata.^[5] Foliniska kiselina se generalno dozira kao kalcijum ili natrijum folinat (ili leukovorin kalcijum/natrijum). Ona se takođe koristi u kombinaciji sa hemoterapijskim agensom 5-fluorouracil.

Levofolininska kiselina i njene soli su enantiočisti lekovi (u ovom slučaju, levo forma). Oni su biološki aktivna forma folinske kiseline.

Foliniska kiselina je okrivena 1948. kao citrovorum faktor i povremeno se još uvek koristi pod tim imenom.^[6] Folinska kiselina se razlikuje od folne kiseline (Vitamina B9). Folinska kiselina je provitamin folne kiseline, i ima punu aktivnost tog vitamina.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Keshava C, Keshava N, Whong WZ, Nath J, Ong TM (February 1998). „Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells”. Mutat. Res. 397 (2): 221–8. DOI:10.1016/S0027-5107(97)00216-9. PMID 9541646.
↑ Citrovorum factor discovery

Spoljašnje veze

U.S. National Library of Medicine: Drug Information Portal - Folinic acid

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid9541646-5] Keshava C, Keshava N, Whong WZ, Nath J, Ong TM (February 1998). „Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells”. Mutat. Res. 397 (2): 221–8. DOI:10.1016/S0027-5107(97)00216-9. PMID 9541646.

[6] Citrovorum factor discovery

[1]