Lana Salih Joelsson

Have you read: “Sarcopenia definitions and their association with injurious falls in older Swedish women from the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone fractures (SUPERB) study” You should! https://lnkd.in/efC28ftP Introduction: Focus of Research: This study investigated the association between different sarcopenia definitions and the risk of injurious falls in older women. Researchers compared three widely used definitions: Sarcopenia Definitions and Outcomes Consortium (SDOC), revised European Working Group on Sarcopenia in Older People (EWGSOP2), and Asian Working Group for Sarcopenia (AWGS). Methods: Study Population: The study was conducted within the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures (SUPERB) cohort. Study included 2,883 women aged 75–80 years, randomly recruited from the Swedish national population register. Sarcopenia Assessment: They employed three sarcopenia definitions: SDOC (based on muscle function and strength), EWGSOP2, and AWGS (both incorporating muscle mass measurements). Data Collection: Incident injurious falls were identified via the Swedish National Patient Register and baseline questionnaires. Statistical analyses were conducted using Cox regression models, adjusting for age, BMI, previous falls, and comorbidity. Results: Prevalence of Sarcopenia: Prevalence was highest with the EWGSOP2 definition (12.5%) and lowest with SDOC (4.5%). Key Findings: Only the SDOC definition was significantly associated with an increased risk of injurious falls, both with (HR 2.11) and without fractures (HR 2.16). Definitions incorporating muscle mass (EWGSOP2 and AWGS) did not show significant associations with fall risk. Sensitivity and Competing Risk Analysis: The relationship between SDOC-defined sarcopenia and injurious falls remained consistent, even after accounting for competing mortality risks. Discussion: Interpretation of Findings: These findings suggest that muscle function and strength are more relevant than muscle mass in predicting injurious falls in older women. The SDOC definition, focused on these aspects, outperformed other definitions in identifying individuals at risk. Clinical Implications: These results support the prioritization of muscle function assessments in clinical settings for fall risk prediction and prevention. Limitations: The study was limited to ambulatory women aged 75-80, which may affect generalizability to other populations. Conclusion: Main Takeaway: The SDOC sarcopenia definition should be considered more effective for assessing fall risk in older adults, emphasizing the need for muscle function-focused assessments. Future Directions: They recommend further research to refine sarcopenia definitions and validate these findings across diverse populations, including men and non-ambulatory older adults.

9

Epidemiological Seminar II with Professor George Davey Smith 📍 Center for Health and Society (CSS), Øster Farimagsgade 5, Copenhagen, Room 1.1.02 We are fortunate to have George Davey Smith delivering two seminars for us. On November 15th, he will be presenting the second one, Triangulation - Causal inference approaches to observational epidemiology data. Below, you’ll find a brief description of the seminar content. Aetiological epidemiology aims to identify causal influences on disease risk, with randomized controlled trials (RCTs) often considered the gold standard for intervention evidence. However, it’s impractical to conduct large-scale RCTs for every potential cause. Triangulation is an approach that combines findings from diverse study types to strengthen causal inference, emphasizing that variety in evidence can enhance inferential strength. This method requires that biases are unrelated across study designs. For example, the effects of HDL cholesterol on coronary heart disease risk can be explored through both RCTs and Mendelian randomization, with each method’s unique biases providing independent insights. Triangulation methods in observational epidemiology include negative controls, instrumental variables, and quasi-experimental designs, with pre-registered protocols enhancing confidence in results. For more information about George Davey Smith, please refer to the flyer for his seminar on November 14th. We hope you’ll join us for what promises to be an inspiring seminar.

63

3 kommentarer

New Research on Clozapine Treatment Outcomes We’re proud to highlight groundbreaking research co-authored by our team member, @Ari Ahola-Olli, which was recently published in the American Journal of Psychiatry. This study uncovers the high burden of ileus and pneumonia in patients undergoing clozapine treatment, shedding light on critical challenges faced in the treatment of schizophrenia. The findings emphasize the importance of early detection and personalized care to mitigate risks associated with clozapine, reinforcing our commitment to improving patient outcomes through innovative approaches and precision medicine. At Abomics, we strive to contribute to the future of pharmacogenomics in psychiatry by supporting research and providing solutions that make a real impact on patients’ lives. Read the full study and join the conversation on how we can tackle these challenges together. #Pharmocogenomics #Psychiatry #Clozapine #Schizophrenia #MentalHealth #PrecisionMedicine #HealthcareInnovation #Abomics

4

Epidemiological Seminar I with Professor George Davey Smith 📍 Center for Health and Society (CSS), Øster Farimagsgade 5, Copenhagen,  Room 1.1.02   We are fortunate to welcome Professor George Davey Smith, leading figure in clinical epidemiology, to the University of Copenhagen, where he will be hosting TWO Epidemiological Seminars. The first seminar will take place on November 14th, during which he will discuss Mendelian Randomization. Below, you will find a brief description of the seminar content, along with Professor Smith’s biography.   Mendelian Randomization (MR) uses genetic variation to improve causal inference on how modifiable exposures affect disease outcomes. While few papers were published in MR’s first decade, there has been an exponential rise since then, though many are uninformative or nonsensical. In this seminar, Smith will revisit the core assumption of MR—gene-environment equivalence—and the conditions for causal effect identification. Grouping the threats in three headings: “Noodles”, “No Nulls” and “Numb Sculls”, Smith will address these issues, suggest solutions, and introduce promising future directions.   George Davey Smith is a clinical epidemiologist focused on improving causal inference in disease studies. His work includes the use of ‘negative controls’, cross-context comparisons, sensitivity analyses, unobtrusive data collection, and trials in challenging settings. He pioneered the use of germline genetic variants for investigating modifiable causes of disease (‘Mendelian randomization’), developed extensions of the method, and applied it widely. He advocates for using multiple methods with different bias structures (‘triangulation’) to strengthen causal inference.   We hope to see you, participation is free and open to everyone.

51

4 kommentarer

🤰🏻🤰🏾 𝐑𝐞𝐭𝐡𝐢𝐧𝐤𝐢𝐧𝐠 𝐆𝐞𝐬𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐃𝐢𝐚𝐛𝐞𝐭𝐞𝐬: 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐋𝐚𝐧𝐜𝐞𝐭 𝐒𝐞𝐫𝐢𝐞𝐬 from two co-authors in the series, DDEA Visiting Researcher, Professor Patrick Catalano, and former DDA grant recipient, Senior Researcher Karoline Kragelund Nielsen. 𝐀𝐛𝐨𝐮𝐭 𝐆𝐞𝐬𝐭𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐃𝐢𝐚𝐛𝐞𝐭𝐞𝐬 𝐌𝐞𝐥𝐥𝐢𝐭𝐮𝐬 According to The Lancet, Gestational Diabetes Mellitus (GDM) is the most common medical pregnancy complication worldwide. 🌎 Early diagnosis and treatment is greatly needed to improve the health of both woman and child 👩🏿👶🏿 The Lancet series presents insights into the pathophysiology and management of GDM 𝐂𝐡𝐚𝐧𝐠𝐢𝐧𝐠 𝐭𝐡𝐞 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐨𝐟 𝐆𝐃𝐌 Professor Catalano co-authored two papers in the series, 'Pathophysiology from preconception, during pregnancy, and beyond' and ‘Epidemiology and management of GDM' "𝘛𝘩𝘦 𝘤𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘮𝘢𝘯𝘪𝘧𝘦𝘴𝘵𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘩𝘪𝘨𝘩 𝘨𝘭𝘶𝘤𝘰𝘴𝘦, 𝘶𝘴𝘦𝘥 𝘵𝘰 𝘥𝘪𝘢𝘨𝘯𝘰𝘴𝘦 𝘎𝘋𝘔, 𝘰𝘤𝘤𝘶𝘳𝘴 𝘣𝘦𝘤𝘢𝘶𝘴𝘦 𝘰𝘧 𝘱𝘭𝘢𝘤𝘦𝘯𝘵𝘢𝘭 𝘧𝘢𝘤𝘵𝘰𝘳𝘴 𝘪𝘯 𝘱𝘳𝘦𝘨𝘯𝘢𝘯𝘤𝘺 𝘸𝘩𝘪𝘤𝘩 𝘢𝘭𝘵𝘦𝘳 𝘪𝘯𝘴𝘶𝘭𝘪𝘯 𝘴𝘦𝘯𝘴𝘪𝘵𝘪𝘷𝘪𝘵𝘺 𝘢𝘯𝘥 𝘱𝘢𝘯𝘤𝘳𝘦𝘢𝘵𝘪𝘤 𝘣𝘦𝘵𝘢 𝘤𝘦𝘭𝘭 𝘧𝘶𝘯𝘤𝘵𝘪𝘰𝘯. 𝑻𝒉𝒊𝒔 𝒅𝒆𝒎𝒐𝒏𝒔𝒕𝒓𝒂𝒕𝒆𝒔 𝒕𝒉𝒂𝒕 𝑮𝑫𝑴 𝒊𝒔 𝒂 𝒎𝒆𝒕𝒂𝒃𝒐𝒍𝒊𝒄 𝒅𝒊𝒔𝒂𝒐𝒓𝒅𝒆𝒓 𝒕𝒉𝒂𝒕 𝒆𝒙𝒊𝒔𝒕𝒔 𝒑𝒓𝒊𝒐𝒓 𝒕𝒐 𝒄𝒐𝒏𝒄𝒆𝒑𝒕𝒊𝒐𝒏,” explains Professor Patrick Catalano about his findings. 🔗 Learn more about Catalano's research, including how metabolic adaptations to pregnancy affect lipids: https://buff.ly/3T9gdnQ 𝐀𝐝𝐝𝐫𝐞𝐬𝐬𝐢𝐧𝐠 𝐊𝐞𝐲 𝐁𝐚𝐫𝐫𝐢𝐞𝐫𝐬 Karoline Kragelund Nielsen is a Senior Researcher at Steno Diabetes Center Copenhagen. She is part of the Face-it project which aims to reduce the risk of diabetes and increase the quality of life of families where the mother has a history of GDM with a tailored postpartum intervention programme 👪 Nielsen is co-author of the paper in the Lancet titled 'Call to action for a life course approach' ♻️ “𝘞𝘰𝘮𝘦𝘯 𝘸𝘪𝘵𝘩 𝘱𝘳𝘪𝘰𝘳 𝘎𝘋𝘔 𝘢𝘳𝘦 𝘢𝘵 𝘩𝘪𝘨𝘩 𝘳𝘪𝘴𝘬 𝘰𝘧 𝘥𝘦𝘷𝘦𝘭𝘰𝘱𝘪𝘯𝘨 𝘵𝘺𝘱𝘦 2 𝘥𝘪𝘢𝘣𝘦𝘵𝘦𝘴. 𝘉𝘶𝘵 𝐰𝐞'𝐫𝐞 𝐦𝐢𝐬𝐬𝐢𝐧𝐠 𝐭𝐡𝐞 𝐨𝐩𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐭𝐲 𝐟𝐨𝐫 𝐩𝐫𝐨𝐩𝐞𝐫 𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐟𝐨𝐥𝐥𝐨𝐰-𝐮𝐩,” says Nielsen. She points to two key barriers: Resources and the fragmentation of GDM care from primary care 𝐌𝐞𝐞𝐭 𝐭𝐡𝐞 𝐀𝐮𝐭𝐡𝐨𝐫𝐬 Learn more below 🔗with direct links to the Lancet series and the Face-it project, or visit Nielsen's presentation on the Face-it study at European Association for the Study of Diabetes e.V. (EASD) next week. Participants in our upcoming event 𝐌𝐚𝐭𝐞𝐫𝐧𝐚𝐥-𝐅𝐞𝐭𝐚𝐥 𝐈𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐨𝐧𝐬 𝐢𝐧 𝐇𝐞𝐚𝐥𝐭𝐡 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 will meet both Prof. Catalono and Senior Researcher Nielsen 👏🏾 🖊️ Mie Tomzak #DDEA #Research #GDM #Lancet

58

1 kommentar

The article explains why ADHD women instinctively feel, behave and are different through out there cycle. Sometimes we get those terrible months that feel like a blur, when overwhelm and stress feel larger and less manageable. A helpful empowering therapeutic tool to bring back clarity and groundedness, is to create a timeline of your month. Then plot down difficult days, briefly explaining what happened and how you felt. Then track this timeline alongside your monthly cycle. So interesting to see the influences estrogen is having throughout the month. I have found this therapeutic tool so helpful to build awareness of our body, mind and souls needs and want’s during different times.

2

https://lnkd.in/dY2iz7Eu We would highly recommend taking a look at our publication. TITLE Guideline for Diagnosis and Treatment of Osteoporosis in Transfusion Dependent Thalassemia Patients ABSTRACT The health-related quality of life and management of patients with thalassemia has significantly improved in recent years due to standard treatments and safe blood transfusions with effective chelation therapy to reduce iron overload. Transfusion-dependent thalassemia is associated with numerous skeletal abnormalities, including osteoporosis, which is a significant cause of morbidity in these patients. Osteoporosis is characterized by low bone mass and an increased risk of fractures, particularly in the lumbar spine and in patients with extramedullary hematopoiesis. It remains a significant problem in adult transfusion-dependent thalassemia, particularly in patients under chelation therapy. A fracture history is significantly associated with lower Dual-Energy X-ray Absorptiometry (DEXA) T/Z scores, which decrease with age. Improved management and modern treatments for transfusion-dependent thalassemia patients with osteoporosis should be prioritized to prevent bone fractures and improve quality of life in older age.

10

Many patients with bipolar disorder experience difficulties with emotional cognition, encompassing how we perceive, process, and react emotionally in social contexts. However, there is limited insight into the neurocircuitry targets for potential interventions for emotional cognitive deficits. In a newly published article from Hanne Lie Kjærstad et al., we investigate the neural underpinnings of emotional cognition impairments in bipolar disorder. 🧠 🔍Key Highlights: 👥 Distinct Subgroups: We identified two distinct emotional cognition subgroups among patients with bipolar disorder: one characterized by heightened emotional reactivity in negative social scenarios but otherwise intact, and the other exhibiting widespread emotional cognitive impairments. 🧠 Neural Activity Differences: Patients in the ‘heightened reactivity subgroup’ showed stable left amygdala hyperactivity over time during emotion reactivity, while those in the ‘globally impaired subgroup’ exhibited hypoactivity in the left dorsolateral prefrontal cortex during emotion regulation. ☑ Implications: Our findings suggest that broad impairments in emotional cognition may originate from insufficient recruitment of prefrontal resources, contributing to poorer clinical outcomes in bipolar disorder Access the full article here: https://lnkd.in/gWg_43nh This publication represents the collaborative effort of our team. A huge thank you to our collaborators Luisa de Siqueira Rotenberg and Professor Beny Lafer from the University of Sao Paulo.

20

How are natural surroundings (green and blue space) and cardiovascular disease (CVD) related? In just-published research from Yujing Li and our Københavns Universitet - University of Copenhagen collaboration (Jiawei Zhang, Jasper Schipperijn, Stéphane Tuffier, Samuel Hyman, Marie Bergmann, Matthias Ketzel, Claus Backalarz, Zorana Jovanovic Andersen & Youn-Hee Lim ), we saw that: 1. Distance from home to woodland was positively associated with stroke incidence. 2. Distance from home to heathland was inversely associated with CVD incidence. 3. Total number of residential green and blue spaces within a 5000 m radius of home was negatively linked to CVD incidence, indicating cumulative benefits and spatial dependency of these natural spaces. 4. Socioeconomic status and urbanicity level did not alter our observed associations. Read the open-access article online now: https://lnkd.in/gCbUqnfn

36

New insights about situation with Dermacentor reticulatus ticks in Bosnia and Hercegovina. Manuscript is published within Special Issue Ticks and Tick-Borne Pathogens in the Balkans https://lnkd.in/dr6trcya #bosniaandherzegovina #mdpi #ticks #balkans

17

Jorgensen A, Brandslund I, Ellervik C, et al. Oxidative Stress-Induced Damage to RNA and DNA and Mortality in Individuals with Psychiatric Illness. JAMA Psychiatry. 2024;81(5):516–520. doi:10.1001/jamapsychiatry.2024.0052 *********************************** This cohort study aimed to investigate the levels of markers of oxidative stress-induced damage to RNA and DNA in individuals with psychiatric illness and their association with all-cause mortality. The study included 7728 participants, of whom 40.0% had a history of psychiatric illness. The results showed that levels of RNA damage were higher in individuals with psychiatric illness compared to those without, and all-cause mortality was higher in the psychiatric illness group. The study suggests that RNA damage from oxidation may play a role in the accelerated aging observed in psychiatric disorders and could serve as a marker of mortality risk in these individuals. https://lnkd.in/dk66AHMA

2

✨ New Publication! 🧠 We are excited to share the newly published paper from Jussi Sipilä's group on the survival outcomes for people with multiple sclerosis (pwMS) over the past five decades in Western Finland! 🔎 The study examined the impact of disease-modifying treatments (DMTs) such as interferon and glatiramer acetate on the survival rates of individuals diagnosed with MS between 1971 and 2010. Despite advances in treatment, the relative life expectancy for pwMS hasn't changed significantly over the decades. 📉 On average, pwMS had a life expectancy of 8–9 years shorter than the matched controls, with the survival gap appearing within the first-decade post-diagnosis. Read more about the research outcomes here ⬇ https://lnkd.in/dkv9x-Q2 #codedtoconnect #turkubrainandmind #connectingbrains Neurocenter Finland

7

Thyroid hormones are critical for neural development, and during the first trimester of pregnancy the fetus relies fully on maternal thyroid hormone production. By the use of The Copenhagen Primary Care Laboratory (CopLab) Database data, Line Tang Møllehave set out to investigate the associations between maternal thyroid hormone levels in the first trimester with the child’s school performance, risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Read Line´s article here 👉 https://lnkd.in/dmmwPa53

25

2 kommentarer

Unraveling the metabolomic architecture of autism in a large Danish population-based cohort. The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental, and prenatal factors, the molecular etiology of autism is largely unknown. Here, we use untargeted metabolomics to characterize the neonatal metabolome from dried blood spots collected shortly after birth. METHODS: We analyze the metabolomic profiles of a subset of a large Danish population-based cohort (iPSYCH2015) consisting of over 1400 newborns, who later are diagnosed with autism and matching controls and in two Swedish population-based cohorts comprising over 7000 adult participants. Mass spectrometry analysis was performed by a timsTOF Pro operated in QTOF mode, using data-dependent acquisition. By applying an untargeted metabolomics approach, we could reproducibly measure over 800 metabolite features. RESULTS: We detected underlying molecular perturbations across several metabolite classes that precede autism. In particular, the cyclic dipeptide cyclo-leucine-proline (FDR-adjusted p = 0.003) and the carnitine-related 5-aminovaleric acid betaine (5-AVAB) (FDR-adjusted p = 0.03), were associated with an increased probability for autism, independently of known prenatal and genetic risk factors. Analysis of genetic and dietary data in adults revealed that 5-AVAB was associated with increased habitual dietary intake of dairy (FDR-adjusted p < 0.05) and with variants near SLC22A4 and SLC22A5 (p < 5.0e - 8), coding for a transmembrane carnitine transporter protein involved in controlling intracellular carnitine levels. CONCLUSIONS: Cyclo-leucine-proline and 5-AVAB are associated with future diagnosis of autism in Danish neonates, both representing novel early biomarkers for autism. 5-AVAB is potentially modifiable and may influence carnitine homeostasis. Source: BMC Med https://lnkd.in/eakY5rWN

4

🤗#CallforReading Title: Intelligent Digital Twins for Personalized Migraine Care #Migraine 👨‍🔬 Parisa Gazerani 🏥 Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway 🔗https://lnkd.in/ezi7M6GB #mdpijpm✔️ Figure 1. A proposed overview of the application of intelligent digital twins for the personalized care of migraines.

1

I think this is a spot on depiction of the landscape of GCing on many continents. It's interesting to consider, given the diverse healthcare systems, insurance, and resources, how the issues we face appear to be universal and if solutions to challenges in one region will translate to another. It also makes me wonder: what is it about GCing that has us all facing the same issues. Are the qualities that make our profession an asset also impeding our progress?

9

1 kommentar

Now we have Steffen Syrbe 🤩🇩🇪 sharing with us “The spectrum of CACNA1A-related disorders” at the #DICE224 6th Dianalund International Conference on #Epilepsy! #precisionmedicine #genetics #neurology

7