Wicked problem approaches such as problem- and project-based learning initiate robust learning processes. When coupled with design-based research, solutions to educational problems can be iteratively developed and implemented. Research-practice partnerships provide means to engage in this design activity. This paper explains the relationship among wicked problems, design-based research, and research-practice partnerships and how they provide a framework for understanding how research and practice can be reciprocal and why this is valuable in the learning sciences.