Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and,
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …

Background Asthma treatment guidelines recommend increasing corticosteroid dose to
control symptoms and reduce exacerbations. This approach is potentially flawed because …

There is a recognized need for new treatment options for type 2 diabetes mellitus (T2DM).
Recovery of glucose from the glomerular filtrate represents an important mechanism in …

Background Diabetes, a highly prevalent, chronic disease, is associated with increasing
frailty and functional decline in older people, with concomitant personal, social, and public …

Sarcoidosis is a multisystem inflammatory disease, the aetiology of which has still to be
resolved. The proposed mechanism is that a susceptible genotype is exposed to one or more …

Phenotype-specific omic expression patterns in people with frailty could provide invaluable
insight into the underlying multi-systemic pathological processes and targets for intervention. …

Rationale: The past 25 years have seen huge progress in understanding of the pathobiology
of type-2 (T2) asthma, identification of measurable biomarkers, and the emergence of novel …

Background Approximately 5% to 10% of patients with asthma have severe disease, with a
consistent preponderance in females. Current asthma guidelines recommend stepwise …

Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with
greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary …

Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC),
with variable propensity for progression. We perform multiscale, integrated molecular …