[HTML][HTML] Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer
…, HR Davies, L Fu, A Grigoriadis, TM Hardman…�- Nature�…, 2022 - nature.com
Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and,
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …
[HTML][HTML] Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre�…
…, A Woodcock, SM Walker, TC Hardman…�- The Lancet�…, 2021 - thelancet.com
Background Asthma treatment guidelines recommend increasing corticosteroid dose to
control symptoms and reduce exacerbations. This approach is potentially flawed because …
control symptoms and reduce exacerbations. This approach is potentially flawed because …
[HTML][HTML] Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes
TC Hardman, SW Dubrey�- Diabetes Therapy, 2011 - Springer
There is a recognized need for new treatment options for type 2 diabetes mellitus (T2DM).
Recovery of glucose from the glomerular filtrate represents an important mechanism in …
Recovery of glucose from the glomerular filtrate represents an important mechanism in …
[HTML][HTML] An evaluation of the effectiveness of a multi-modal intervention in frail and pre-frail older people with type 2 diabetes-the MID-Frail study: study protocol for a�…
…, A Zeyfang, M Izquierdo, O Laosa, TC Hardman…�- Trials, 2014 - Springer
Background Diabetes, a highly prevalent, chronic disease, is associated with increasing
frailty and functional decline in older people, with concomitant personal, social, and public …
frailty and functional decline in older people, with concomitant personal, social, and public …
Sarcoidosis: the links between epidemiology and aetiology
S Dubrey, S Shah, T Hardman…�- Postgraduate medical�…, 2014 - academic.oup.com
Sarcoidosis is a multisystem inflammatory disease, the aetiology of which has still to be
resolved. The proposed mechanism is that a susceptible genotype is exposed to one or more …
resolved. The proposed mechanism is that a susceptible genotype is exposed to one or more …
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts
…, FJ Garcia-Garcia, J Carnicero, TC Hardman…�- Geroscience, 2021 - Springer
Phenotype-specific omic expression patterns in people with frailty could provide invaluable
insight into the underlying multi-systemic pathological processes and targets for intervention. …
insight into the underlying multi-systemic pathological processes and targets for intervention. …
Exacerbation profile and risk factors in a type-2–low enriched severe asthma cohort: a clinical trial to assess asthma exacerbation phenotypes
…, A Woodcock, S Walker, TC Hardman…�- American journal of�…, 2022 - atsjournals.org
Rationale: The past 25 years have seen huge progress in understanding of the pathobiology
of type-2 (T2) asthma, identification of measurable biomarkers, and the emergence of novel …
of type-2 (T2) asthma, identification of measurable biomarkers, and the emergence of novel …
[HTML][HTML] A randomized trial of a composite T2-biomarker strategy adjusting corticosteroid treatment in severe asthma: a post hoc analysis by sex
…, A Woodcock, S Walker, TC Hardman…�- The Journal of Allergy�…, 2023 - Elsevier
Background Approximately 5% to 10% of patients with asthma have severe disease, with a
consistent preponderance in females. Current asthma guidelines recommend stepwise …
consistent preponderance in females. Current asthma guidelines recommend stepwise …
[HTML][HTML] Minimal barriers to invasion during human colorectal tumor growth
Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with
greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary …
greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary …
[HTML][HTML] Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC),
with variable propensity for progression. We perform multiscale, integrated molecular …
with variable propensity for progression. We perform multiscale, integrated molecular …