Dopamine type 2 and type 3 receptors (D₂R/D₃R) appear critical to addictive disorders. Cocaine-use disorder (CUD) is associated with lower D₂R availability and greater D₃R availability in regions primarily expressing D₂R or D₃R concentrations, respectively. However, these CUD-related alterations in D₂R and D₃R have not been concurrently detected using available dopaminergic radioligands. Furthermore, receptor availability in regions of mixed D₂R/D₃R concentration in CUD remains unclear. The current study aimed to extend investigations of CUD-related alterations in D₂R and D₃R availability using regional and source-based analyses of [¹¹C]-(+)-PHNO positron emission tomography (PET) of 26 individuals with CUD and 26 matched healthy comparison (HC) participants. Regional analysis detected greater binding potential (BP_ND) in CUD in the midbrain, consistent with prior [¹¹C]-(+)-PHNO research, and lower BP_ND in CUD in the dorsal striatum, consistent with research using non-selective D₂R/D₃R radiotracers. Exploratory independent component analysis (ICA) identified three sources of BP_ND (striatopallidal, pallidonigral, and mesoaccumbens sources) that represent systems of brain regions displaying coherent variation in receptor availability. The striatopallidal source was associated with estimates of regional D₂R-related proportions of BP_ND (calculated using independent reports of [¹¹C]-(+)-PHNO receptor binding fractions), was lower in intensity in CUD and negatively associated with years of cocaine use. By comparison, the pallidonigral source was associated with estimates of regional D₃R distribution, was greater in intensity in CUD and positively associated with years of cocaine use. The current study extends previous D₂R/D₃R research in CUD, demonstrating both lower BP_ND in the D₂R-rich dorsal striatum and greater BP_ND in the D₃R-rich midbrain using a single radiotracer. In addition, exploratory ICA identified sources of [¹¹C]-(+)-PHNO BP_ND that were correlated with regional estimates of D₂R-related and D₃R-related proportions of BP_ND, were consistent with regional differences in CUD, and suggest receptor alterations in CUD may also be present in regions of mixed D₂R/D₃R concentration.