User profiles for Nikolaos P. Daskalakis
 | Nikolaos P. Daskalakis, MD PhDAssociate Professor of Psychiatry, McLean Hospital, Harvard Medical School, Harvard�… Verified email at mclean.harvard.edu Cited by 8118 |
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful …
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful …
Holocaust exposure induced intergenerational effects on FKBP5 methylation
R Yehuda, NP Daskalakis, LM Bierer, HN Bader…�- Biological�…, 2016 - Elsevier
… Author links open overlay panel Rachel Yehuda a b , Nikolaos P. Daskalakis a b , Linda
M. Bierer a b , Heather N. Bader a b , Torsten Klengel c f , Florian Holsboer d e , Elisabeth B. …
M. Bierer a b , Heather N. Bader a b , Torsten Klengel c f , Florian Holsboer d e , Elisabeth B. …
Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring
Objective Differential effects of maternal and paternal posttraumatic stress disorder (PTSD)
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …
[HTML][HTML] Early life stress effects on glucocorticoid—BDNF interplay in the hippocampus
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …
biological effects of ELS are manifested in stress-susceptible regions of the hippocampus …
[HTML][HTML] Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD
R Yehuda, NP Daskalakis, F Desarnaud…�- Frontiers in�…, 2013 - frontiersin.org
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known
whether these measures associate with, or predict, clinical state. These questions were …
whether these measures associate with, or predict, clinical state. These questions were …
Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder
…, F Desarnaud, I Makotkine, NP Daskalakis…�- Biological�…, 2015 - Elsevier
Background Enhanced glucocorticoid receptor (GR) sensitivity is present in people with
posttraumatic stress disorder (PTSD), but the molecular mechanisms of GR sensitivity are not …
posttraumatic stress disorder (PTSD), but the molecular mechanisms of GR sensitivity are not …
Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment
NP Daskalakis, A Lehrner…�- …�and Metabolism Clinics, 2013 - endo.theclinics.com
Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder that can develop in
trauma survivors. 1 The diagnosis is based on symptoms in 3 distinct clusters: re-…
trauma survivors. 1 The diagnosis is based on symptoms in 3 distinct clusters: re-…
Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes
NP Daskalakis, H Cohen, G Cai…�- Proceedings of the�…, 2014 - National Acad Sciences
Delineating the molecular basis of individual differences in the stress response is critical to
understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In …
understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In …
New translational perspectives for blood-based biomarkers of PTSD: from glucocorticoid to immune mediators of stress susceptibility
Although biological systems have evolved to promote stress-resilience, there is variation in
stress-responses. Understanding the biological basis of such individual differences has …
stress-responses. Understanding the biological basis of such individual differences has …