Insulin dosage optimization based on prediction of postprandial glucose excursions under uncertain parameters and food intake
Computer Methods and Programs in biomedicine, 2012•Elsevier
Considering the difficulty in selecting correct insulin doses and the problem of hyper-and
hypoglycemia episodes in type 1 diabetes, dosage-aid systems are very useful for these
patients. A model-based approach to this problem must unavoidably consider uncertainty
sources such as large intra-patient variability and food intake. In the present study,
postprandial glucose is predicted considering this uncertain information using modal interval
analysis. This approach calculates a safer prediction of possible hyper-and hypoglycemia�…
hypoglycemia episodes in type 1 diabetes, dosage-aid systems are very useful for these
patients. A model-based approach to this problem must unavoidably consider uncertainty
sources such as large intra-patient variability and food intake. In the present study,
postprandial glucose is predicted considering this uncertain information using modal interval
analysis. This approach calculates a safer prediction of possible hyper-and hypoglycemia�…
Considering the difficulty in selecting correct insulin doses and the problem of hyper- and hypoglycemia episodes in type 1 diabetes, dosage-aid systems are very useful for these patients. A model-based approach to this problem must unavoidably consider uncertainty sources such as large intra-patient variability and food intake. In the present study, postprandial glucose is predicted considering this uncertain information using modal interval analysis. This approach calculates a safer prediction of possible hyper- and hypoglycemia episodes induced by insulin therapy for an individual patient's parameters and integrates this information into a dosage-aid system. Predictions of a patient's postprandial glucose at 5-h intervals are used to predict the risk for a given therapy. Then the insulin dose and injection-to-meal time with the lowest risk are calculated. The method has been validated for three different scenarios corresponding to preprandial glucose values of 100, 180 and 250mg/dl.
Elsevier
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