Objective: To analyze the effect of white matter lesions in different brain regions on regional
cortical glucose metabolism, regional cortical atrophy, and cognitive function in a sample …

Background and Purpose— MRI segmentation and mapping techniques were used to
assess evidence in support of categorical distinctions between periventricular white matter …

Background Previous studies have identified effects of age and vascular risk factors on
brain injury in elderly individuals. We aimed to establish whether the effects of high blood …

Objective To evaluate relationships between magnetic resonance imaging (MRI)–based
measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, …

In a previous study using positron emission tomography (PET), we demonstrated that focused
attention to a location in the visual field produced increased regional cerebral blood flow …

Importance Magnetic resonance imaging markers of incipient cognitive decline among healthy
elderly individuals have become important for both clarifying the biological underpinnings …

Objective: Examine how longitudinal cognitive trajectories relate to brain baseline measures
and change in lobar volumes in a racially/ethnically and cognitively diverse sample of older …

Abstract Changes in memory function in elderly individuals are often attributed to dysfunction
of the prefrontal cortex (PFC). One mechanism for this dysfunction may be disruption of …

The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate …

Background and Purpose— White matter hyperintensities (WMHs) are associated with
progressive age-related cognitive decline and cardiovascular risk factors, but their biological …