Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory
and activation receptors for major histocompatibility complex class I molecules as a means of …

Background Although coinfection with HIV-1 and hepatitis B virus (HBV) is common, few
long-term studies on liver-disease mortality in coinfected people have been undertaken. Our …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

The propeptide of furin has multiple roles in guiding the activation of the endoprotease in
vivo. The 83-residue N-terminal propeptide is autoproteolytically excised in the endoplasmic …

PURPOSE: To describe the relationship of body mass index (BMI) with postoperative
complications and resource utilization. PATIENTS AND METHODS: Two thousand nine hundred …

Background: The data used by the US Institute of Medicine to estimate deaths from medical
errors come from a study that relied on nurse and physician reviews of medical records to …

Background Constipation is a distressing side effect of opioid treatment. As a quaternary amine,
methylnaltrexone, a μ-opioid–receptor antagonist, has restricted ability to cross the blood…

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

… of community work as an occupation; David Thomas tries to clarify its contribution to a number
of … Thomas presents his ideas clearly, and his ability to look critically at some of the basic …