User profiles for Ashok Thillaisundaram

Ashok Thillaisundaram

Microsoft Research
Verified email at microsoft.com
Cited by 1072

Accurate structure prediction of biomolecular interactions with AlphaFold 3

…, P Savy, S Singh, A Stecula, A Thillaisundaram…�- Nature, 2024 - nature.com
The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure of
proteins and their interactions, enabling a huge range of applications in protein modelling and …

Biomedical relation extraction with pre-trained language representations and minimal task-specific architecture

A Thillaisundaram, T Togia�- arXiv preprint arXiv:1909.12411, 2019 - arxiv.org
This paper presents our participation in the AGAC Track from the 2019 BioNLP Open Shared
Tasks. We provide a solution for Task 3, which aims to extract "gene - function change - …

De novo design of high-affinity protein binders with AlphaProteo

…, RG Schneider, D Saxton, A Thillaisundaram…�- arXiv preprint arXiv�…, 2024 - arxiv.org
Computational design of protein-binding proteins is a fundamental capability with broad
utility in biomedical research and biotechnology. Recent methods have made strides against …

Constructing large scale biomedical knowledge bases from scratch with rapid annotation of interpretable patterns

J Fauqueur, A Thillaisundaram, T Togia�- arXiv preprint arXiv:1907.01417, 2019 - arxiv.org
Knowledge base construction is crucial for summarising, understanding and inferring
relationships between biomedical entities. However, for many practical applications such as drug …

A Hierarchical Transformer for Unsupervised Parsing

A Thillaisundaram�- arXiv preprint arXiv:2003.13841, 2020 - arxiv.org
The underlying structure of natural language is hierarchical; words combine into phrases,
which in turn form clauses. An awareness of this hierarchical structure can aid machine …

Signatures of Brane Inflation

A Thillaisundaram�- arXiv preprint arXiv:1208.1042, 2012 - arxiv.org
We study slow-roll inflation on a three-brane in a five-dimensional bulk where the effects of
energy loss from the brane due to graviton emission is included in a self-consistent manner. …

Aspects of fluid dynamics and the fluid/gravity correspondence

A Thillaisundaram - 2017 - repository.cam.ac.uk
This thesis considers various extensions to the fluid/gravity correspondence as well as
problems fundamental to the study of fluid dynamics. The fluid/gravity correspondence is a map …

[PDF][PDF] Topics in High-dimensional and Large-scale Data Analysis

RD Shah - 2014 - Citeseer
The problem of variable selection has received a huge amount of attention over the last 15
years, motivated by the desire to understand structure in massive datasets that are now …

Learning to extend molecular scaffolds with structural motifs

K Maziarz, H Jackson-Flux, P Cameron…�- arXiv preprint arXiv�…, 2021 - arxiv.org
Recent advancements in deep learning-based modeling of molecules promise to accelerate
in silico drug discovery. A plethora of generative models is available, building molecules …

The contact property for magnetic flows on surfaces

G Benedetti�- arXiv preprint arXiv:1805.04916, 2018 - arxiv.org
This is the author's PhD Thesis (University of Cambridge, 2014) in its original form. In the
first part, using an invariance result, we compute the symplectic homology of contact-type …