We are far from understanding how best to design, implement, and use health information technology (IT). A comprehensive framework, developed by Rippen et al 1 to capture and organize knowledge on the implementation, use, and optimization of health IT, may guide and inform more effective health IT deployment. This study applied Rippen’s framework to a focused type of health IT–alerts–through clinical decision support (CDS), an area with a substantial evidence base around many facets of implementation, including the technology, use, and outcomes. We report results from applying this framework for capturing, organizing and standardizing knowledge and related measures around alerts. It is clear there are gaps in information shared and that measures across studies vary significantly. Insights identified using the framework highlight areas for further study and development, directed toward a shared conceptualization and representation of knowledge, and ultimately, a more comprehensive and deeper understanding of health IT.