[HTML][HTML] 3D visualization of macromolecule synthesis
TJ Duerr, E Comellas, EK Jeon, JE Farkas, M Joetzjer…�- Elife, 2020 - elifesciences.org
Measuring nascent macromolecular synthesis in vivo is key to understanding how cells and
tissues progress through development and respond to external cues. Here we perform in�…
tissues progress through development and respond to external cues. Here we perform in�…
A constitutively expressed fluorescent ubiquitination-based cell-cycle indicator (FUCCI) in axolotls for studying tissue regeneration
TJ Duerr, EK Jeon, KM Wells, A Villanueva…�- …, 2022 - journals.biologists.com
Regulation of cell cycle progression is essential for cell proliferation during regeneration
following injury. After appendage amputation, the axolotl (Ambystoma mexicanum)�…
following injury. After appendage amputation, the axolotl (Ambystoma mexicanum)�…
[HTML][HTML] Wnt signaling coordinates the expression of limb patterning genes during axolotl forelimb development and regeneration
After amputation, axolotl salamanders can regenerate their limbs, but the degree to which
limb regeneration recapitulates limb development remains unclear. One limitation in�…
limb regeneration recapitulates limb development remains unclear. One limitation in�…
[HTML][HTML] Patient-reported wellbeing and clinical disease measures over time captured by multivariate trajectories of disease activity in individuals with juvenile�…
SJW Shoop-Worrall, KL Hyrich…�- The Lancet�…, 2021 - thelancet.com
Background Juvenile idiopathic arthritis (JIA) is a heterogeneous disease, the signs and
symptoms of which can be summarised with use of composite disease activity measures�…
symptoms of which can be summarised with use of composite disease activity measures�…
How can trial designs better serve the needs of children and young people with juvenile idiopathic arthritis?
FL Feilding, L Crosby, E Earle, R Beesley…�- The Lancet�…, 2024 - thelancet.com
In juvenile idiopathic arthritis we have seen remarkable progress in the number of available
licensed biological and small molecule treatments in the past two decades, leading to�…
licensed biological and small molecule treatments in the past two decades, leading to�…
Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis
Movement-induced forces are critical to correct joint formation, but it is unclear how cells
sense and respond to these mechanical cues. To study the role of mechanical stimuli in the�…
sense and respond to these mechanical cues. To study the role of mechanical stimuli in the�…
Lung injury in axolotl salamanders induces an organ‐wide proliferation response
TB Jensen, P Giunta, NG Schultz…�- Developmental�…, 2021 - Wiley Online Library
Background Ambystoma mexicanum, the axolotl salamander, is a classic model organism
used to study vertebrate regeneration. It is assumed that axolotls regenerate most tissues�…
used to study vertebrate regeneration. It is assumed that axolotls regenerate most tissues�…
Investigating cell cycle regulation and morphogenesis during axolotl limb development and regeneration
TJ Duerr - 2021 - search.proquest.com
Mammals, including humans, are severely limited in their capability for limb regeneration,
only being able to regenerate amputated digit tips. Axolotl salamanders (Ambystoma�…
only being able to regenerate amputated digit tips. Axolotl salamanders (Ambystoma�…
Hybridization Chain Reaction Fluorescence In Situ Hybridization (HCR-FISH) in Ambystoma mexicanum Tissue
In situ hybridization is a standard procedure for visualizing mRNA transcripts in tissues. The
recent adoption of fluorescent probes and new signal amplification methods have facilitated�…
recent adoption of fluorescent probes and new signal amplification methods have facilitated�…
[HTML][HTML] Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts
SJW Shoop-Worrall, S Lawson-Tovey…�- Ebiomedicine, 2024 - thelancet.com
Background Methotrexate (MTX) is the gold-standard first-line disease-modifying anti-
rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or�…
rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or�…