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Regulation of IRF3 activation in human antiviral signaling pathways.

Al Hamrashdi M, Brady G. Al Hamrashdi M, et al. Biochem Pharmacol. 2022 Jun;200:115026. doi: 10.1016/j.bcp.2022.115026. Epub 2022 Mar 31. Biochem Pharmacol. 2022. PMID: 35367198 Free article. Review.

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Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling.

Harding O, Holzer E, Riley JF, Martens S, Holzbaur ELF. Harding O, et al. Mol Cell. 2023 Sep 7;83(17):3188-3204.e7. doi: 10.1016/j.molcel.2023.08.005. Mol Cell. 2023. PMID: 37683611 Free PMC article.

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NF-κB, IκB, and IKK: Integral Components of Immune System Signaling.

Mulero MC, Huxford T, Ghosh G. Mulero MC, et al. Adv Exp Med Biol. 2019;1172:207-226. doi: 10.1007/978-981-13-9367-9_10. Adv Exp Med Biol. 2019. PMID: 31628658 Review.

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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.

Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D. Balka KR, et al. Cell Rep. 2020 Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. Cell Rep. 2020. PMID: 32268090 Free article.

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IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.

Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. Schmacke NA, et al. Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Immunity. 2022. PMID: 36384135 Free PMC article.

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The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.

Gu L, Zhu Y, Lin X, Lu B, Zhou X, Zhou F, Zhao Q, Prochownik EV, Li Y. Gu L, et al. Hepatology. 2021 Jan;73(1):160-174. doi: 10.1002/hep.31249. Epub 2020 Nov 6. Hepatology. 2021. PMID: 32221968

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Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses.

Huang Z, Shen S, Han X, Li W, Luo W, Lin L, Xu M, Wang Y, Huang W, Wu G, Liang G. Huang Z, et al. EMBO Mol Med. 2023 May 8;15(5):e17198. doi: 10.15252/emmm.202217198. Epub 2023 Mar 10. EMBO Mol Med. 2023. PMID: 36896602 Free PMC article.

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ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.

Cai D, Sun C, Murashita T, Que X, Chen SY. Cai D, et al. Circ Res. 2023 Feb 17;132(4):e78-e93. doi: 10.1161/CIRCRESAHA.122.321722. Epub 2023 Jan 23. Circ Res. 2023. PMID: 36688311 Free PMC article.

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PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-κB pathway and PD-L1 expression.

Zhang Z, Sun D, Tang H, Ren J, Yin S, Yang K. Zhang Z, et al. J Immunother Cancer. 2023 Nov;11(11):e007627. doi: 10.1136/jitc-2023-007627. J Immunother Cancer. 2023. PMID: 37914384 Free PMC article.

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Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB.

Du M, Ea CK, Fang Y, Chen ZJ. Du M, et al. Mol Cell. 2022 Jul 7;82(13):2415-2426.e5. doi: 10.1016/j.molcel.2022.03.037. Epub 2022 Apr 26. Mol Cell. 2022. PMID: 35477005 Free PMC article.

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