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. 1975 Jun;72(6):2357-60.
doi: 10.1073/pnas.72.6.2357.

Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes

C A Janeway Jr, N Sakato, H N Eisen

Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes

C A Janeway Jr et al. Proc Natl Acad Sci U S A. 1975 Jun.

Abstract

The ability of thymus-derived lymphocytes (T cells) from BALB/c mice to recognize the individually specific antigenic determinants (idiotypes) of BALB/c myeloma proteins was tested. Spleen cells from donor mice immunized with a given myeloma protein greatly augmented the response of hapten-specific bone marrow-derived, thymus-independent lymphocytes (cells) to a hapten conjugate of the immunizing myeloma protein. This helper effect was specific for the myeloma protein idiotype; responses to hapten conjugates of similar myeloma proteins, bearing different idiotypic determinants, were not augmented by these spleen cells. That the helper cell is a T cell was shown by its marked sensitivity to cytolysis with an isoantiserum specific for T cells (anti-Thy-1-2) and complement. The discrimination between idiotypes by such T cells is roughly comparable to that of the antibody produced by the donors of the helper cells.

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